4-(6-(5-(5-(4-methoxybenzylamino)-1,3,4-thiadiazol-2-yl)-1-tosyl-1H-indol-3-yl)pyridin-2-yl)-1-methylpiperazin-2-one

Base Information

Chemical Name:4-(6-(5-(5-(4-methoxybenzylamino)-1,3,4-thiadiazol-2-yl)-1-tosyl-1H-indol-3-yl)pyridin-2-yl)-1-methylpiperazin-2-one
CAS No.:1401349-02-7
Molecular Formula:C₃₅H₃₃N₇O₄S₂
Molecular Weight:679.824
Hs Code.:

Synonyms:4-(6-(5-(5-(4-methoxybenzylamino)-1,3,4-thiadiazol-2-yl)-1-tosyl-1H-indol-3-yl)pyridin-2-yl)-1-methylpiperazin-2-one

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Chemical Property of 4-(6-(5-(5-(4-methoxybenzylamino)-1,3,4-thiadiazol-2-yl)-1-tosyl-1H-indol-3-yl)pyridin-2-yl)-1-methylpiperazin-2-one

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Technology Process of 4-(6-(5-(5-(4-methoxybenzylamino)-1,3,4-thiadiazol-2-yl)-1-tosyl-1H-indol-3-yl)pyridin-2-yl)-1-methylpiperazin-2-one

There total 7 articles about 4-(6-(5-(5-(4-methoxybenzylamino)-1,3,4-thiadiazol-2-yl)-1-tosyl-1H-indol-3-yl)pyridin-2-yl)-1-methylpiperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401348-75-1
5-(3-(6-fluoropyridin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-thiadiazol-2-amine

: 59702-07-7
1-methylpiperazin-2-one

: 1401349-02-7
4-(6-(5-(5-(4-methoxybenzylamino)-1,3,4-thiadiazol-2-yl)-1-tosyl-1H-indol-3-yl)pyridin-2-yl)-1-methylpiperazin-2-one

Guidance literature:: With triethylamine; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 60h; Microwave irradiation;

Reference yield:

: 842136-58-7
2-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 1401349-02-7
4-(6-(5-(5-(4-methoxybenzylamino)-1,3,4-thiadiazol-2-yl)-1-tosyl-1H-indol-3-yl)pyridin-2-yl)-1-methylpiperazin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / 1,4-dioxane; water / 0.5 h / 105 °C / Microwave irradiation

2: triethylamine / 1-methyl-pyrrolidin-2-one / 60 h / 150 °C / Microwave irradiation

With potassium phosphate; triethylamine; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water;

Reference yield:

: 1401348-60-4
2-(1H-indol-5-yl)-5-(methylthio)-1,3,4-thiadiazole

: 1401349-02-7
4-(6-(5-(5-(4-methoxybenzylamino)-1,3,4-thiadiazol-2-yl)-1-tosyl-1H-indol-3-yl)pyridin-2-yl)-1-methylpiperazin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 2 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 8 h / 20 °C

3: sodium tungstate; dihydrogen peroxide / water; acetic acid / 72 h / 20 °C

4: 1,4-dioxane / 20 - 100 °C

5: potassium phosphate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / 1,4-dioxane; water / 0.5 h / 105 °C / Microwave irradiation

6: triethylamine / 1-methyl-pyrrolidin-2-one / 60 h / 150 °C / Microwave irradiation

With sodium tungstate; potassium phosphate; dihydrogen peroxide; iodine; sodium hydride; triethylamine; potassium hydroxide; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; acetic acid; N,N-dimethyl-formamide; mineral oil;