59702-07-7

Basic information

• Product Name: 1-Methylpiperazin-2-one
• Synonyms: 1-METHYL-PIPERAZIN-2-ONE;1-METHYL-PIPERAZINE-2-ONE;2-Piperazinone, 1-methyl-;1-Methylpiperazin-2-one ,98%;1-Methylpiperazin-2-one ,97%;-Methyl-piperazin-2-one;1-methylpiperazin-2-one(SALTDATA: HCl);1-Methyl-2-piperazinone
• CAS NO: 59702-07-7
• Molecular Formula: C₅H₁₀N₂O
• Molecular Weight: 114.15
• Mol File: 59702-07-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 242.12 °C at 760 mmHg
• Flash Point: 100.231 °C
• Appearance: /
• Density: 1.037 g/cm³
• Vapor Pressure: 0.035mmHg at 25°C
• Refractive Index: 1.461
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 7.42±0.20(Predicted)
• CAS DataBase Reference: 1-Methylpiperazin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methylpiperazin-2-one(59702-07-7)
• EPA Substance Registry System: 1-Methylpiperazin-2-one(59702-07-7)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 59702-07-7(Hazardous Substances Data)

Usage

General Description

1-Methylpiperazin-2-one, also known as N-methylpiperazinone, is a chemical compound with the molecular formula C5H10N2O. It is a cyclic amine oxide that is used in various industrial applications, including as a solvent and as an intermediate in the production of pharmaceuticals and agrochemicals. It is a clear, colorless liquid with a slightly amine-like odor, and is soluble in water, alcohols, and ethers. 1-Methylpiperazin-2-one is also used as a polymerization inhibitor and as a corrosion inhibitor in the oil and gas industry. It is considered to have low toxicity and is not classified as a hazardous substance by regulatory agencies.

InChI:InChI=1/C5H10N2O/c1-7-3-2-6-4-5(7)8/h6H,2-4H2,1H3

Upstream product

• 110-85-0 piperazine 
• 109384-27-2 1-methylpiperazin-2-one hydrochloride 
• 685520-31-4 4-methyl-3-oxopiperazine-1-carboxylic acid benzyl ester 
• 851726-64-2 benzyl (2-((2,2-dimethoxyethyl)(methyl)amino)-2-oxoethyl)carbamate 
• 109384-26-1 1-tert-butoxycarbonyl-4-methyl-3-oxopiperazine 
• 851726-65-3 4-benzyloxycarbonyl-1-methyl-3,4-dihydropyrazin-2(1H)-one 

Downstream Products

• 98106-36-6 6-Fluoro-1-(4-fluoro-phenyl)-7-(4-methyl-3-oxo-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 410545-06-1 N-(4-fluorobenzyl)-8-hydroxy-5-(4-methyl-3-oxopiperazin-1-yl)-1,6-naphthyridine-7-carboxamide 
• 344778-72-9 3-(2-fluorophenyl)-5-(1-methyl-2-oxopiperazin-4-yl)-[1,2,3]triazolo[1,5-a]quinazoline 
• 1135439-58-5 C₁₉H₁₈Cl₂N₂O₃ 
• 1240300-21-3 1-methyl-4-(2-(4-(1-(3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]-pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)piperazin-2-one 
• 86291-02-3 4-(2-hydroxyethyl)-1-methylpiperazin-2-one 
• 1255339-28-6 1-methyl-4-[2-(4-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl}phenoxy)ethyl]piperazin-2-one 
• 1123514-43-1 4-(4-(5-(4-(difluoromethoxy)phenyl)pyrimidin-2-ylamino)benzoyl)-1-methylpiperazin-2-one 
• 870006-59-0 4-bromo-2-(4-fluorobenzyl)-5-(4-methyl-3-oxopiperazin-1-yl)pyridazin-3(2H)-one 

Relevant articles and documents

1,5,7-TRISUBSTITUTED ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN MEDICINES

The present disclosure relates to 1,5,7-trisubstituted isoquinoline derivatives, their preparation and pharmaceutical use. In particular, the present disclosure discloses a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, and a preparation method and use thereof. The definitions of the groups in the formula can be found in the specification and claims.

Containing piperazinone quinazoline ketone PARP - 1/2 inhibitor and its preparation method, pharmaceutical composition and use thereof (by machine translation)

The invention discloses a new class of containing piperazinone quinazoline - 2, 4 (1 H, 3 H) - dione PARP - 1/2 inhibitor, and its preparation and pharmaceutical composition and use. Specifically, the invention relates to the general formula I shown containing of the piperazinone quinazoline - 2, 4 (1 H, 3 H) - dione derivatives and their pharmaceutically acceptable salt, and its preparation method, comprising one or more of the compounds of the composition, and the compounds in the preparation, the prevention and/or treatment with PARP - 1/2 of a disease associated with the use of the medicament. (by machine translation)

PYRAZOLE DERIVATIVE

A compound represented by Formula (I): wherein Ar1 represents Formula (II): Ar2 represents a 5- or 6-membered aromatic heterocyclic group which may be substituted; and X represents Formula (III): a salt thereof, or a solvate of the compound or the salt. A potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.