N-(Cyclohexylmethyl)-2-methylpropan-2-amine

Base Information

• Chemical Name: N-(Cyclohexylmethyl)-2-methylpropan-2-amine
• CAS No.: 65055-37-0
• Molecular Formula: C11H23 N
• Molecular Weight: 169.31
• Hs Code.: 2921300090
• DSSTox Substance ID: DTXSID20466821
• Wikidata: Q82293463
• Mol file: 65055-37-0.mol

Synonyms:65055-37-0;N-(Cyclohexylmethyl)-2-methylpropan-2-amine;TERT-BUTYL-CYCLOHEXYLMETHYL-AMINE;TERT-BUTYL(CYCLOHEXYLMETHYL)AMINE;tert-butylcyclohexylmethylamine;SCHEMBL2524987;DTXSID20466821;SQNQWCLRQYIHJI-UHFFFAOYSA-N;AKOS000133600;CS-0272748;EN300-164143;F8881-8048

Chemical Property of N-(Cyclohexylmethyl)-2-methylpropan-2-amine

Chemical Property:

• PSA: 12.03000
• LogP: 3.34570
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 169.183049738
• Heavy Atom Count: 12
• Complexity: 118

Purity/Quality:

97% ^*data from raw suppliers

TERT-BUTYL-CYCLOHEXYLMETHYL-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)NCC1CCCCC1

Technology Process of N-(Cyclohexylmethyl)-2-methylpropan-2-amine

There total 5 articles about N-(Cyclohexylmethyl)-2-methylpropan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

tert-butylamine (75-64-9) + cyclohexanecarbaldehyde (2043-61-0) → N-tert-butyl-N-(cyclohexylmethyl)amine (65055-37-0)

Guidance literature:

tert-butylamine; cyclohexanecarbaldehyde; In ethanol; at 20 ℃; for 1h;

With hydrogen; palladium on activated charcoal; In ethanol; at 50 ℃; for 12h; under 760 Torr;

DOI:10.1016/j.tet.2004.11.077

Reference yield:

N-(cyclohexylmethylene)-2-methylpropan-2-amine (53188-66-2) → N-tert-butyl-N-(cyclohexylmethyl)amine (65055-37-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 0.166667h; Ambient temperature;

DOI:10.1021/jo960057x

Reference yield:

cyclohexanecarbaldehyde (2043-61-0) → N-tert-butyl-N-(cyclohexylmethyl)amine (65055-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 3 h / Ambient temperature

2: NaBH₄ / methanol / 0.17 h / Ambient temperature

With sodium tetrahydroborate; In methanol;

DOI:10.1021/jo960057x

upstream raw materials:

N-(cyclohexylmethylene)-2-methylpropan-2-amine

tert-butylamine

cyclohexanecarbaldehyde

Downstream raw materials:

N-tert-butyl-N-cyclohexylmethyl-α-diazoacetamide