N-PHENYL-2-AMINOTHIAZOLE

Base Information

• Chemical Name: N-PHENYL-2-AMINOTHIAZOLE
• CAS No.: 33142-18-6
• Molecular Formula: C9H8 N2 S
• Molecular Weight: 176.242
• Hs Code.: 2934100090
• Mol file: 33142-18-6.mol

Synonyms:Thiazole,2-anilino- (8CI); 2-(N-Phenylamino)thiazole; 2-Anilinothiazole;N-Phenyl-2-thiazolamine

Chemical Property of N-PHENYL-2-AMINOTHIAZOLE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Boiling Point: 297.727°C at 760 mmHg
• Flash Point: 133.861°C
• PSA: 53.16000
• Density: 1.275g/cm³
• LogP: 2.95970

Purity/Quality:

98%min ^*data from raw suppliers

N-phenyl-1,3-thiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-PHENYL-2-AMINOTHIAZOLE

There total 13 articles about N-PHENYL-2-AMINOTHIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C5H8ClNOS (76510-73-1) + aniline (62-53-3) → 2-phenylaminothiazole (33142-18-6)

Guidance literature:

C₅H₈ClNOS; aniline; With potassium carbonate; In acetonitrile;

With toluene-4-sulfonic acid; In acetonitrile; at 50 ℃; for 1h;

DOI:10.1002/ejoc.200900092

Reference yield: 90.0%

2-bromo-1,3-thiazole (3034-53-5,215777-74-5) + aniline (62-53-3) → 2-phenylaminothiazole (33142-18-6)

Guidance literature:

With toluene-4-sulfonic acid; In isopropyl alcohol; at 80 ℃; for 72h;

DOI:10.1016/j.bmcl.2011.01.123

Reference yield: 88.0%

monophenylthiourea (103-85-5) → 2-phenylaminothiazole (33142-18-6)

Guidance literature:

With hydrogenchloride; In water; for 2h; Reflux;

DOI:10.1016/j.molstruc.2014.05.009

upstream raw materials:

1,2-dichloroethyl acetate

monophenylthiourea

chloroacetaldehyde diethyl acetal

acetaldehyde

Downstream raw materials:

N-phenyl-N-(thiazol-2-yl)carbamic acid 1,1-dimethylethyl ester

C₂₀H₁₆N₂S₂

C₂₂H₁₇N₃O₂S

N-benzyl-N,5-diphenylthiazol-2-amine

Refernces

• 1、 Babar, Ayesha,Yar, Muhammad,Tarazi, Hamadeh,Duarte, Vera,Alshammari, Mohammed B.,Gilani, Mazhar Amjad,Iqbal, Haffsah,Munawwar, Munawwar Ali,Alves, Maria J.,Khan, Ather Farooq. "Molecular docking and glucosidase inhibition studies of novel N-arylthiazole-2-amines and Ethyl 2-[aryl(thiazol-2-yl)amino]acetates". . p. 3247 - 3261. Retrieved 2017/10/06.
• 2、 Toulot, Stephanie,Heinrich, Timo,Leroux, Frederic R.. "Convenient and reliable routes towards 2-aminothiazoles: Palladium-catalyzed versus copper-catalyzed aminations of halothiazoles". supporting information. p. 3263 - 3272. Retrieved 2013/12/04.