(E)-3-(4-Methoxy-phenyl)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-prop-2-en-1-ol

Base Information

• Chemical Name: (E)-3-(4-Methoxy-phenyl)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-prop-2-en-1-ol
• CAS No.: 1027180-08-0
• Molecular Formula: C₂₈H₂₄F₃NO₄
• Molecular Weight: 495.498
• Mol file: 1027180-08-0.mol

Synonyms:(E)-3-(4-Methoxy-phenyl)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-prop-2-en-1-ol

Chemical Property of (E)-3-(4-Methoxy-phenyl)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-prop-2-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(4-Methoxy-phenyl)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-prop-2-en-1-ol

There total 5 articles about (E)-3-(4-Methoxy-phenyl)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-prop-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-(4-Methoxy-phenyl)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-acrylic acid ethyl ester (1026459-71-1) → (E)-3-(4-Methoxy-phenyl)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-prop-2-en-1-ol (1027180-08-0)

Guidance literature:

With diisobutylaluminium hydride; In diethyl ether; at -78 ℃; for 0.5h;

DOI:10.1021/jm990476x

Reference yield:

4-Trifluoromethylbenzaldehyde (455-19-6) → (E)-3-(4-Methoxy-phenyl)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-prop-2-en-1-ol (1027180-08-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 65 percent / HCl gas / ethyl acetate / 3 h / 5 °C

2.1: 30 percent / POCl₃ / CHCl₃ / 2.5 h / Heating

3.1: K₂CO₃ / dimethylformamide / 10 h / 65 °C

4.1: NaH / toluene / 1 h

4.2: toluene; tetrahydrofuran / 48 h

5.1: DIBAL / diethyl ether / 0.5 h / -78 °C

With hydrogenchloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; trichlorophosphate; In diethyl ether; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene; 1.1: Condensation / 2.1: Chlorination / 3.1: Alkylation / 4.1: Metallation / 4.2: Condensation / 5.1: Reduction;

DOI:10.1021/jm990476x

Reference yield:

4-(chloromethyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole (174258-39-0) → (E)-3-(4-Methoxy-phenyl)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-prop-2-en-1-ol (1027180-08-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: K₂CO₃ / dimethylformamide / 10 h / 65 °C

2.1: NaH / toluene / 1 h

2.2: toluene; tetrahydrofuran / 48 h

3.1: DIBAL / diethyl ether / 0.5 h / -78 °C

With sodium hydride; diisobutylaluminium hydride; potassium carbonate; In diethyl ether; N,N-dimethyl-formamide; toluene; 1.1: Alkylation / 2.1: Metallation / 2.2: Condensation / 3.1: Reduction;

DOI:10.1021/jm990476x

upstream raw materials:

(E)-3-(4-Methoxy-phenyl)-3-{3-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-acrylic acid ethyl ester

4-Trifluoromethylbenzaldehyde

4-(chloromethyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

4,5-dimethyl-2-(4-trifluoromethylphenyl)-oxazole 3-oxide

Downstream raw materials:

C₃₈H₄₁F₃N₂O₈