3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid, Isomer 1

Base Information

Chemical Name:3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid, Isomer 1
CAS No.:954148-11-9
Molecular Formula:C₃₂H₃₉NO₃
Molecular Weight:485.667
Hs Code.:

Synonyms:3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid, Isomer 1

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Chemical Property of 3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid, Isomer 1

Chemical Property:

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Technology Process of 3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid, Isomer 1

There total 9 articles about 3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid, Isomer 1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 954148-10-8
3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid methyl ester, Isomer 1

: 954148-11-9
3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid, Isomer 1

Guidance literature:: With sodium hydroxide; In water;

Reference yield:

: 3-{4-[1-(4-bromo-benzylidene)-3-methyl-butyl]-benzoylamino}-propionic acid methyl ester

: 954148-11-9
3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid, Isomer 1

Guidance literature:: Multi-step reaction with 4 steps

1: potassium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / Heating / reflux

2: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 20 °C / 1551.49 Torr

3: Resolution of racemate

4: sodium hydroxide / water

With potassium fluoride; sodium hydroxide; hydrogen; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In ethanol; water; toluene; 1: Suzuki Coupling;

Reference yield:

: 100757-91-3
1-(p-methoxycarbonylphenyl)-3-methyl-1-butanol

: 954148-11-9
3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid, Isomer 1

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridinium chlorochromate / dichloromethane / 20 °C

2.1: tributylphosphine / dimethyl sulfoxide / 23 h / 60 °C

2.2: 48 h / 20 °C

3.1: sodium hydroxide / tetrahydrofuran; water

3.2: pH 7

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dmap / dichloromethane / 48 h / 20 °C

5.1: potassium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / Heating / reflux

6.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 20 °C / 1551.49 Torr

7.1: Resolution of racemate

8.1: sodium hydroxide / water

With potassium fluoride; sodium hydroxide; tributylphosphine; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; pyridinium chlorochromate; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene; 2.2: Wittig Reaction / 5.1: Suzuki Coupling;