3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid methyl ester, Isomer 1

Base Information

Chemical Name:3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid methyl ester, Isomer 1
CAS No.:954148-10-8
Molecular Formula:C₃₃H₄₁NO₃
Molecular Weight:499.693
Hs Code.:

Synonyms:3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid methyl ester, Isomer 1

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Chemical Property of 3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid methyl ester, Isomer 1

Chemical Property:

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Technology Process of 3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid methyl ester, Isomer 1

There total 8 articles about 3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid methyl ester, Isomer 1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 954147-97-8
3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid methyl ester

: 954148-10-8
3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid methyl ester, Isomer 1

Guidance literature:: Resolution of racemate;

Reference yield:

: 3-{4-[1-(4-bromo-benzylidene)-3-methyl-butyl]-benzoylamino}-propionic acid methyl ester

: 954148-10-8
3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid methyl ester, Isomer 1

Guidance literature:: Multi-step reaction with 3 steps

1: potassium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / Heating / reflux

2: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 20 °C / 1551.49 Torr

3: Resolution of racemate

With potassium fluoride; hydrogen; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In ethanol; water; toluene; 1: Suzuki Coupling;

Reference yield:

: 100757-91-3
1-(p-methoxycarbonylphenyl)-3-methyl-1-butanol

: 954148-10-8
3-{4-[1-(4'-tert-butyl-biphenyl-4-ylmethyl)-3-methyl-butyl]-benzoylamino}-propionic acid methyl ester, Isomer 1

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridinium chlorochromate / dichloromethane / 20 °C

2.1: tributylphosphine / dimethyl sulfoxide / 23 h / 60 °C

2.2: 48 h / 20 °C

3.1: sodium hydroxide / tetrahydrofuran; water

3.2: pH 7

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dmap / dichloromethane / 48 h / 20 °C

5.1: potassium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / Heating / reflux

6.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 20 °C / 1551.49 Torr

7.1: Resolution of racemate

With potassium fluoride; sodium hydroxide; tributylphosphine; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; pyridinium chlorochromate; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene; 2.2: Wittig Reaction / 5.1: Suzuki Coupling;