2-(tert-butyl-dimethyl-silanyl)-5-[2,3,5-tris-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-pentyl]-imidazole-1-sulfonic acid dimethylamide

Base Information

• Chemical Name: 2-(tert-butyl-dimethyl-silanyl)-5-[2,3,5-tris-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-pentyl]-imidazole-1-sulfonic acid dimethylamide
• CAS No.: 613234-31-4
• Molecular Formula: C₄₃H₆₅N₃O₇SSi₂
• Molecular Weight: 824.242
• Mol file: 613234-31-4.mol

Synonyms:2-(tert-butyl-dimethyl-silanyl)-5-[2,3,5-tris-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-pentyl]-imidazole-1-sulfonic acid dimethylamide

Chemical Property of 2-(tert-butyl-dimethyl-silanyl)-5-[2,3,5-tris-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-pentyl]-imidazole-1-sulfonic acid dimethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(tert-butyl-dimethyl-silanyl)-5-[2,3,5-tris-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-pentyl]-imidazole-1-sulfonic acid dimethylamide

There total 4 articles about 2-(tert-butyl-dimethyl-silanyl)-5-[2,3,5-tris-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-pentyl]-imidazole-1-sulfonic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.5%

2-tert-butyldimethylsilyl-N,N-dimethylimidazole-1-sulfonamide (129378-52-5) + 2,3,5-tri-O-benzyl-4-O-tert-butyldimethylsilyl-L-arabinose (613234-29-0) → 2-(tert-butyl-dimethyl-silanyl)-5-[2,3,5-tris-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-pentyl]-imidazole-1-sulfonic acid dimethylamide (613234-31-4) + 2-(tert-butyl-dimethyl-silanyl)-5-[2,3,5-tris-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-pentyl]-imidazole-1-sulfonic acid dimethylamide (613234-30-3)

Guidance literature:

2-tert-butyldimethylsilyl-N,N-dimethylimidazole-1-sulfonamide; With n-butyllithium; tert-butyldimethylsilyl chloride; In tetrahydrofuran; hexane; at -50 ℃; for 0.333333h;

2,3,5-tri-O-benzyl-4-O-tert-butyldimethylsilyl-L-arabinose; In tetrahydrofuran; hexane; at -70 - 20 ℃; for 3h;

DOI:10.1016/S0040-4020(03)01055-X

Reference yield:

2,3,5-tri-O-benzyl-L-arabinofuranose (96192-07-3) → 2-(tert-butyl-dimethyl-silanyl)-5-[2,3,5-tris-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-pentyl]-imidazole-1-sulfonic acid dimethylamide (613234-31-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 61.5 percent / HCl / dioxane / 24 h / 20 °C

2.1: 82 percent / imidazole / dimethylformamide / 20 h / 80 °C

3.1: 48.6 percent / Na₂CO₃; MeI / acetone; H₂O / 16 h / Heating

4.1: n-BuLi; tert-butyldimethylsilyl chloride / hexane; tetrahydrofuran / 0.33 h / -50 °C

4.2: 66.5 percent / tetrahydrofuran; hexane / 3 h / -70 - 20 °C

With 1H-imidazole; hydrogenchloride; n-butyllithium; sodium carbonate; tert-butyldimethylsilyl chloride; methyl iodide; In tetrahydrofuran; 1,4-dioxane; hexane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1016/S0040-4020(03)01055-X

Reference yield:

2,3,5-tri-O-benzyl-L-arabinose ethylenedithioacetal (613234-27-8) → 2-(tert-butyl-dimethyl-silanyl)-5-[2,3,5-tris-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-pentyl]-imidazole-1-sulfonic acid dimethylamide (613234-31-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 82 percent / imidazole / dimethylformamide / 20 h / 80 °C

2.1: 48.6 percent / Na₂CO₃; MeI / acetone; H₂O / 16 h / Heating

3.1: n-BuLi; tert-butyldimethylsilyl chloride / hexane; tetrahydrofuran / 0.33 h / -50 °C

3.2: 66.5 percent / tetrahydrofuran; hexane / 3 h / -70 - 20 °C

With 1H-imidazole; n-butyllithium; sodium carbonate; tert-butyldimethylsilyl chloride; methyl iodide; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1016/S0040-4020(03)01055-X

upstream raw materials:

2-tert-butyldimethylsilyl-N,N-dimethylimidazole-1-sulfonamide

2,3,5-tri-O-benzyl-4-O-tert-butyldimethylsilyl-L-arabinose

2,3,5-tri-O-benzyl-L-arabinofuranose

2,3,5-tri-O-benzyl-L-arabinose ethylenedithioacetal

Downstream raw materials:

(5R,6S,7R,8S)-6,7,8-Tris-benzyloxy-5-benzyloxymethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyridine