4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid

Base Information

Chemical Name:4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid
CAS No.:450840-98-9
Molecular Formula:C₁₃H₁₀ClNO₃
Molecular Weight:263.68
Hs Code.:

Synonyms:4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid

Suppliers and Price of 4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid

There total 12 articles about 4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 450840-94-5
ethyl 4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate

: 450840-98-9
4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 60 ℃; for 8h;
DOI:10.1016/j.bmcl.2004.08.012

Reference yield:

: C₉H₁₃NO₅

: 450840-98-9
4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide / methanol / Reflux

2: triethylamine; dmap / N,N-dimethyl-formamide / 95 °C

3: bis(η3-allyl-μ-chloropalladium(II)); tetrakis(triphenylphosphine) palladium(0); caesium carbonate / water; N,N-dimethyl-formamide / 55 - 65 °C

4: water; potassium hydroxide / methanol / Reflux

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(η3-allyl-μ-chloropalladium(II)); water; caesium carbonate; triethylamine; potassium hydroxide; In methanol; water; N,N-dimethyl-formamide; 3: |Suzuki-Miyaura Coupling;
DOI:10.1021/co3000709

Reference yield:

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 450840-98-9
4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: methanol / 20 °C

2: hydrogenchloride / methanol; water / 20 °C

3: potassium hydroxide / methanol / Reflux

4: triethylamine; dmap / N,N-dimethyl-formamide / 95 °C

5: bis(η3-allyl-μ-chloropalladium(II)); tetrakis(triphenylphosphine) palladium(0); caesium carbonate / water; N,N-dimethyl-formamide / 55 - 65 °C

6: water; potassium hydroxide / methanol / Reflux

With hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(η3-allyl-μ-chloropalladium(II)); water; caesium carbonate; triethylamine; potassium hydroxide; In methanol; water; N,N-dimethyl-formamide; 5: |Suzuki-Miyaura Coupling;
DOI:10.1021/co3000709