ethyl 4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate

Base Information

Chemical Name:ethyl 4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate
CAS No.:450840-94-5
Molecular Formula:C₁₅H₁₄ClNO₃
Molecular Weight:291.734
Hs Code.:

Synonyms:ethyl 4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate

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Chemical Property of ethyl 4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate

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Technology Process of ethyl 4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate

There total 5 articles about ethyl 4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 74-89-5
methylamine

: (E)-3-(3-Chloro-phenyl)-4-formyl-pent-2-enedioic acid diethyl ester

: 450840-94-5
ethyl 4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate

Guidance literature:: methylamine; (E)-3-(3-Chloro-phenyl)-4-formyl-pent-2-enedioic acid diethyl ester; In ethanol; for 0.5h; Heating;

With potassium carbonate; In ethanol; at 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2004.08.012

Reference yield:

: diethyl 3-(3-chlorophenyl)-4-(hydroxymethylene)-2-pentenedioate

: 450840-94-5
ethyl 4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate

Guidance literature:: With potassium carbonate; acetic acid; methylamine; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 625-99-0
3-iodochlorobenzene

: 450840-94-5
ethyl 4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 20 percent / Pd(OAc)2; NaOAc / dimethylformamide / 21 h / 100 °C

2.1: 96 percent / NaH / diethyl ether / 2 h / 20 °C

3.1: ethanol / 0.5 h / Heating

3.2: 41 percent / K₂CO₃ / ethanol / 18 h / 20 °C

With palladium diacetate; sodium acetate; sodium hydride; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.08.012