3-(2,6-dichlorophenyl)-4-(4'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole

Base Information

• Chemical Name: 3-(2,6-dichlorophenyl)-4-(4'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole
• CAS No.: 1573119-79-5
• Molecular Formula: C₂₈H₂₂Cl₃NO₄
• Molecular Weight: 542.846
• Mol file: 1573119-79-5.mol

Synonyms:3-(2,6-dichlorophenyl)-4-(4'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole

Chemical Property of 3-(2,6-dichlorophenyl)-4-(4'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2,6-dichlorophenyl)-4-(4'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole

There total 4 articles about 3-(2,6-dichlorophenyl)-4-(4'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-(2,6-dichlorophenyl)-4-(4'-methoxycarbonyl-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole (1573119-80-8) → 3-(2,6-dichlorophenyl)-4-(4'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole (1573119-79-5)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃;

DOI:10.1002/cmdc.201300305

Reference yield:

[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methanol (278597-30-1) → 3-(2,6-dichlorophenyl)-4-(4'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole (1573119-79-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

3.1: potassium hydroxide / ethanol / 20 °C

With di-isopropyl azodicarboxylate; sodium hydride; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; mineral oil;

DOI:10.1002/cmdc.201300305

Reference yield:

Methyl 4-(bromomethyl)benzoate (2417-72-3) → 3-(2,6-dichlorophenyl)-4-(4'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole (1573119-79-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 2 h / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

3.1: potassium hydroxide / ethanol / 20 °C

With sodium hydride; potassium hydroxide; In tetrahydrofuran; ethanol; mineral oil;

DOI:10.1002/cmdc.201300305

upstream raw materials:

[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methanol

Methyl 4-(bromomethyl)benzoate

3-(2,6-dichlorophenyl)-4-(4'-methoxycarbonyl-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole

methyl 3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazole-4-carboxylate