(R)-N-(2,4-dichlorophenyl)methylene-2-methylpropane-2-sulfinamide

Base Information

• Chemical Name: (R)-N-(2,4-dichlorophenyl)methylene-2-methylpropane-2-sulfinamide
• CAS No.: 1015198-52-3
• Molecular Formula: C₁₁H₁₃Cl₂NOS
• Molecular Weight: 278.202
• Mol file: 1015198-52-3.mol

Synonyms:(R)-N-(2,4-dichlorophenyl)methylene-2-methylpropane-2-sulfinamide

Chemical Property of (R)-N-(2,4-dichlorophenyl)methylene-2-methylpropane-2-sulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-(2,4-dichlorophenyl)methylene-2-methylpropane-2-sulfinamide

There total 1 articles about (R)-N-(2,4-dichlorophenyl)methylene-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,4-dichlorobenzaldeyhde (874-42-0) + (R)-2-methylpropane-2-sulfinamide (196929-78-9) → (R)-N-(2,4-dichlorophenyl)methylene-2-methylpropane-2-sulfinamide (1015198-52-3)

Guidance literature:

With titanium(IV) isopropylate; In tetrahydrofuran; at 40 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.08.030

Reference yield: 99.0%

(R)-N-(2,4-dichlorophenyl)methylene-2-methylpropane-2-sulfinamide (1015198-52-3) + 1-(4-bromophenyl)-1-propen-3-yl bromide (96090-12-9,124854-99-5) → (R)-N-((1R,2R)-2-(4-bromophenyl)-1-(2,4-dichlorophenyl)but-3-enyl)-2-methylpropane-2-sulfinamide (1259080-15-3)

Guidance literature:

With lithium chloride; zinc; In N,N-dimethyl-formamide; at 20 ℃; for 2h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c0cc03230a

Reference yield: 99.0%

(R)-N-(2,4-dichlorophenyl)methylene-2-methylpropane-2-sulfinamide (1015198-52-3) + (E)-3-bromoprop-1-enyl benzoate (500756-90-1) → (1S,2R)-1-(2,4-dichlorophenyl)-1-((R)-1,1-dimethylethylsulfinamido)but-3-en-2-yl benzoate (1198053-86-9)

Guidance literature:

With zinc; In N,N,N,N,N,N-hexamethylphosphoric triamide; water; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1002/chem.200900801

upstream raw materials:

2,4-dichlorobenzaldeyhde

(R)-2-methylpropane-2-sulfinamide

Downstream raw materials:

C₁₄H₁₉Cl₂NOS

(1S,2R)-1-(2,4-dichlorophenyl)-1-((R)-1,1-dimethylethylsulfinamido)but-3-en-2-yl benzoate

(R)-N-((1R,2R)-2-(4-bromophenyl)-1-(2,4-dichlorophenyl)but-3-enyl)-2-methylpropane-2-sulfinamide

(Rs)-2-methyl-N-((S)-2,2,2-trichloro-1-(2,4-dichlorophenyl)ethyl)propane-2-sulfinamide