4-(2-hydroxy-1-methylethyl)-3-nitro-N,N-diphenylbenzenecarboxamide

Base Information

• Chemical Name: 4-(2-hydroxy-1-methylethyl)-3-nitro-N,N-diphenylbenzenecarboxamide
• CAS No.: 702643-12-7
• Molecular Formula: C₂₂H₂₀N₂O₄
• Molecular Weight: 376.412
• Mol file: 702643-12-7.mol

Synonyms:4-(2-hydroxy-1-methylethyl)-3-nitro-N,N-diphenylbenzenecarboxamide

Chemical Property of 4-(2-hydroxy-1-methylethyl)-3-nitro-N,N-diphenylbenzenecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-hydroxy-1-methylethyl)-3-nitro-N,N-diphenylbenzenecarboxamide

There total 3 articles about 4-(2-hydroxy-1-methylethyl)-3-nitro-N,N-diphenylbenzenecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-ethyl-3-nitro-N,N-diphenyl-benzenecarboxamide (702642-70-4) → 4-(2-hydroxy-1-methylethyl)-3-nitro-N,N-diphenylbenzenecarboxamide (702643-12-7)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 1.5h;

DOI:10.1002/hlca.200490060

Reference yield:

4-Ethyl-3-nitrobenzoic acid (103440-95-5) → 4-(2-hydroxy-1-methylethyl)-3-nitro-N,N-diphenylbenzenecarboxamide (702643-12-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / thionyl chloride / 4 h / Heating

2: 97 percent / dioxane

3: 28 percent / tBuOK / dimethylsulfoxide / 1.5 h / 20 °C

With thionyl chloride; potassium tert-butylate; In 1,4-dioxane; dimethyl sulfoxide;

DOI:10.1002/hlca.200490060

Reference yield:

4-ethyl-3-nitrobenzoyl chloride (702644-48-2) → 4-(2-hydroxy-1-methylethyl)-3-nitro-N,N-diphenylbenzenecarboxamide (702643-12-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / dioxane

2: 28 percent / tBuOK / dimethylsulfoxide / 1.5 h / 20 °C

With potassium tert-butylate; In 1,4-dioxane; dimethyl sulfoxide;

DOI:10.1002/hlca.200490060

upstream raw materials:

formaldehyd

4-ethyl-3-nitro-N,N-diphenyl-benzenecarboxamide

4-Ethyl-3-nitrobenzoic acid

4-ethyl-3-nitrobenzoyl chloride