(2S)-2-((R)-(5-chloro-2-(methoxymethoxy)phenyl)(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidine

Base Information

Chemical Name:(2S)-2-((R)-(5-chloro-2-(methoxymethoxy)phenyl)(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidine
CAS No.:1357176-51-2
Molecular Formula:C₂₈H₃₁ClN₂O₃
Molecular Weight:479.019
Hs Code.:

Synonyms:(2S)-2-((R)-(5-chloro-2-(methoxymethoxy)phenyl)(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidine

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Chemical Property of (2S)-2-((R)-(5-chloro-2-(methoxymethoxy)phenyl)(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidine

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Technology Process of (2S)-2-((R)-(5-chloro-2-(methoxymethoxy)phenyl)(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidine

There total 1 articles about (2S)-2-((R)-(5-chloro-2-(methoxymethoxy)phenyl)(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 83610-87-1
9-desoxy-9-chloroquinine

: 201748-37-0
2-bromo-4-chloro-1-(methoxymethoxy)benzene

: 1357176-51-2
(2S)-2-((R)-(5-chloro-2-(methoxymethoxy)phenyl)(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidine

Guidance literature:: 2-bromo-4-chloro-1-(methoxymethoxy)benzene; With magnesium; In tetrahydrofuran; ethylene dibromide; Inert atmosphere; Reflux;

9-desoxy-9-chloroquinine; In tetrahydrofuran; Reflux; Inert atmosphere;
DOI:10.1039/c1cc14684j

Reference yield: 83.0%

: 1357176-51-2
(2S)-2-((R)-(5-chloro-2-(methoxymethoxy)phenyl)(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidine

: (8S,9R)-9-(5-2-chlorohydroxyphenyl)-6'-methoxy-10,11-dihydro-cinchonan

Guidance literature:: (2S)-2-((R)-(5-chloro-2-(methoxymethoxy)phenyl)(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidine; With hydrogenchloride; In water; for 16h; Inert atmosphere;

With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; for 0.5h; under 760.051 Torr; Inert atmosphere;
DOI:10.1039/c1cc14684j