2-Bromo-4-chloro-1-(methoxymethoxy)benzene

Base Information

• Chemical Name: 2-Bromo-4-chloro-1-(methoxymethoxy)benzene
• CAS No.: 201748-37-0
• Molecular Formula: C8H8 Br Cl O2
• Molecular Weight: 251.507
• DSSTox Substance ID: DTXSID50443802
• Wikidata: Q82261755
• Mol file: 201748-37-0.mol

Synonyms:2-bromo-4-chloro-1-(methoxymethoxy)benzene;201748-37-0;SCHEMBL1371009;DTXSID50443802;JGBXJHJKMUVZKL-UHFFFAOYSA-N;AKOS015965111;5-chloro-2-(methoxymethyloxy)bromobenzene;FT-0752241

Chemical Property of 2-Bromo-4-chloro-1-(methoxymethoxy)benzene

Chemical Property:

• Boiling Point: 283.2±30.0 °C(Predicted)
• PSA: 18.46000
• Density: 1.529±0.06 g/cm3(Predicted)
• LogP: 3.08520
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 249.93962
• Heavy Atom Count: 12
• Complexity: 134

Purity/Quality:

2-BROMO-4-CHLORO-1-(METHOXYMETHOXY)BENZENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCOC1=C(C=C(C=C1)Cl)Br

Technology Process of 2-Bromo-4-chloro-1-(methoxymethoxy)benzene

There total 1 articles about 2-Bromo-4-chloro-1-(methoxymethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-bromo-4-chlorophenol (695-96-5) + chloromethyl methyl ether (107-30-2) → 2-bromo-4-chloro-1-(methoxymethoxy)benzene (201748-37-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 5h; Ambient temperature;

DOI:10.1248/cpb.45.1994

Reference yield: 70.0%

2-ethynyl-1-methyl-3-(propylsulfonyl)benzene (1240287-07-3) + 2-bromo-4-chloro-1-(methoxymethoxy)benzene (201748-37-0) → 3-{[5-chloro-2-(methoxymethoxy)phenyl]ethynyl}-4-methylphenyl propyl sulfone (1240289-05-7)

Guidance literature:

With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triphenylphosphine; In triethylamine; at 80 ℃; Inert atmosphere;

DOI:10.1021/jm200866y

Reference yield: 35.0%

9-desoxy-9-chloroquinine (83610-87-1) + 2-bromo-4-chloro-1-(methoxymethoxy)benzene (201748-37-0) → (2S)-2-((R)-(5-chloro-2-(methoxymethoxy)phenyl)(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidine (1357176-51-2)

Guidance literature:

2-bromo-4-chloro-1-(methoxymethoxy)benzene; With magnesium; In tetrahydrofuran; ethylene dibromide; Inert atmosphere; Reflux;

9-desoxy-9-chloroquinine; In tetrahydrofuran; Reflux; Inert atmosphere;

DOI:10.1039/c1cc14684j

upstream raw materials:

2-bromo-4-chlorophenol

chloromethyl methyl ether

Downstream raw materials:

(5-Chloro-2-hydroxy-phenyl)-(3-hydroxy-pyridin-2-yl)-methanone

(5-Chloro-2-hydroxy-phenyl)-(3-hydroxy-pyridin-2-yl)-methanone O-tert-butyl-oxime

5-chloro-2-methoxymethoxy-[carboxyl-⁽¹⁴⁾C]benzoic acid

3-{[5-chloro-2-(methoxymethoxy)phenyl]ethynyl}-4-methylphenyl propyl sulfone

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