(2R,4R/S)-5-tert-butyldiphenylsilyloxy-2-fluoro-4-iodopentanoic acid methyl ester

Base Information

Chemical Name:(2R,4R/S)-5-tert-butyldiphenylsilyloxy-2-fluoro-4-iodopentanoic acid methyl ester
CAS No.:479035-90-0
Molecular Formula:C₂₂H₂₈FIO₃Si
Molecular Weight:514.451
Hs Code.:

Synonyms:(2R,4R/S)-5-tert-butyldiphenylsilyloxy-2-fluoro-4-iodopentanoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4R/S)-5-tert-butyldiphenylsilyloxy-2-fluoro-4-iodopentanoic acid methyl ester

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Technology Process of (2R,4R/S)-5-tert-butyldiphenylsilyloxy-2-fluoro-4-iodopentanoic acid methyl ester

There total 4 articles about (2R,4R/S)-5-tert-butyldiphenylsilyloxy-2-fluoro-4-iodopentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 5-(tert-butyl-diphenyl-silanyloxy)-2-fluoro-4-hydroxy-pentanoic acid methyl ester

: 479035-90-0
(2R,4R/S)-5-tert-butyldiphenylsilyloxy-2-fluoro-4-iodopentanoic acid methyl ester

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In toluene; at 60 ℃; for 4h;
DOI:10.1021/jm020376i

Reference yield:

: 212954-52-4
(R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-fluoro-5H-furan-2-one

: 479035-90-0
(2R,4R/S)-5-tert-butyldiphenylsilyloxy-2-fluoro-4-iodopentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C

2: NaOH

3: I₂; PPh₃; imidazole

With 1H-imidazole; sodium hydroxide; hydrogen; iodine; triphenylphosphine; palladium on activated charcoal;
DOI:10.1081/NCN-120021965

Reference yield:

: 398133-29-4
(2R,4R)-(-)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-butyrolactone

: 479035-90-0
(2R,4R/S)-5-tert-butyldiphenylsilyloxy-2-fluoro-4-iodopentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH

2: I₂; PPh₃; imidazole

With 1H-imidazole; sodium hydroxide; iodine; triphenylphosphine;
DOI:10.1081/NCN-120021965