C₄₀H₄₆N₆O₈

Base Information

• Chemical Name: C₄₀H₄₆N₆O₈
• CAS No.: 1354652-69-9
• Molecular Formula: C₄₀H₄₆N₆O₈
• Molecular Weight: 738.841
• Mol file: 1354652-69-9.mol

Synonyms:C₄₀H₄₆N₆O₈

Chemical Property of C₄₀H₄₆N₆O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₀H₄₆N₆O₈

There total 9 articles about C₄₀H₄₆N₆O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

C44H54N6O8 (1354653-07-8) → C40H46N6O8 (1354652-69-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

5-amino-2-phenylpyrimidine (59808-52-5) → C40H46N6O8 (1354652-69-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 25 °C

2.1: hydrogen / palladium on activated charcoal / ethyl acetate; ethanol / 2 h / 20 °C

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 25 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 40 °C

4.2: pH 3 - 4

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With dmap; lithium hydroxide monohydrate; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

2-nitro-5-(piperidin-N-yl)-benzoic acid (118159-39-0) → C40H46N6O8 (1354652-69-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 25 °C

2.1: hydrogen / palladium on activated charcoal / ethyl acetate; ethanol / 2 h / 20 °C

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 25 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 40 °C

4.2: pH 3 - 4

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With dmap; lithium hydroxide monohydrate; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

5-amino-2-phenylpyrimidine

3-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-propionic acid tert-butyl ester

2-nitro-5-(piperidin-N-yl)-benzoic acid

tert-butyl 3-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]propanoate