24-triphenylmethoxy-5β-cholan-3α,7α,12α-triol

Base Information

• Chemical Name: 24-triphenylmethoxy-5β-cholan-3α,7α,12α-triol
• CAS No.: 203795-56-6
• Molecular Formula: C₄₃H₅₆O₄
• Molecular Weight: 636.915
• Mol file: 203795-56-6.mol

Synonyms:24-triphenylmethoxy-5β-cholan-3α,7α,12α-triol

Chemical Property of 24-triphenylmethoxy-5β-cholan-3α,7α,12α-triol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 24-triphenylmethoxy-5β-cholan-3α,7α,12α-triol

There total 3 articles about 24-triphenylmethoxy-5β-cholan-3α,7α,12α-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3α,7α,12α-trihydroxycholan-24-ol (3758-71-2) + trityl chloride (76-83-5) → 24-triphenylmethoxy-5β-cholan-3α,7α,12α-triol (203795-56-6)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1039/b307995c

Reference yield:

methyl cholate (1448-36-8) → 24-triphenylmethoxy-5β-cholan-3α,7α,12α-triol (203795-56-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / LiAlH₄ / tetrahydrofuran

2: 90 percent / Et₃N / dimethylformamide

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja973881r

Reference yield:

cholic acid (81-25-4) → 24-triphenylmethoxy-5β-cholan-3α,7α,12α-triol (203795-56-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / LiAlH₄ / tetrahydrofuran / 20 °C

2: 93 percent / Et₃N; DBU / dimethylformamide / 24 h / 20 °C

With lithium aluminium tetrahydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1039/b307995c

upstream raw materials:

3α,7α,12α-trihydroxycholan-24-ol

trityl chloride

cholic acid

methyl cholate

Downstream raw materials:

3α,7α,12α-triallyloxy-24-trityloxy-5β-cholane

C₄₄H₇₈N₄O₃