(2R,4aR,7R,8aR)-2-((R)-1-Benzyloxy-ethyl)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalene

Base Information

Chemical Name:(2R,4aR,7R,8aR)-2-((R)-1-Benzyloxy-ethyl)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalene
CAS No.:191982-83-9
Molecular Formula:C₂₀H₃₀O₂S
Molecular Weight:334.523
Hs Code.:

Synonyms:(2R,4aR,7R,8aR)-2-((R)-1-Benzyloxy-ethyl)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalene

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Chemical Property of (2R,4aR,7R,8aR)-2-((R)-1-Benzyloxy-ethyl)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalene

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Technology Process of (2R,4aR,7R,8aR)-2-((R)-1-Benzyloxy-ethyl)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalene

There total 2 articles about (2R,4aR,7R,8aR)-2-((R)-1-Benzyloxy-ethyl)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 100-39-0
benzyl bromide

: 112067-00-2
(R)-1-((2R,4aR,7R,8aR)-4,4,7-Trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-ethanol

: 191982-83-9
(2R,4aR,7R,8aR)-2-((R)-1-Benzyloxy-ethyl)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalene

Guidance literature:: With tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; In tetrahydrofuran; for 0.666667h; Heating;
DOI:10.1007/BF00807309

Reference yield:

: 79618-03-4
(4aR,7R,8aR)-4,4,7-Trimethyl-hexahydro-1-oxa-3-thia-naphthalene

: 191982-83-9
(2R,4aR,7R,8aR)-2-((R)-1-Benzyloxy-ethyl)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: 44 percent / nBuLi / tetrahydrofuran / 1) -78 deg C, 4 h, 2) to r.t., overnight

2: 95 percent / NaH, Bu₄NSO₄H / tetrahydrofuran / 0.67 h / Heating

With n-butyllithium; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; In tetrahydrofuran;
DOI:10.1007/BF00807309

Reference yield:

: 191982-83-9
(2R,4aR,7R,8aR)-2-((R)-1-Benzyloxy-ethyl)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalene

: 100836-85-9
(R)-2-benzyloxypropionic acid

: 79563-63-6
(3aR,6R,7aR)-3,3,6-Trimethyl-hexahydro-benzo[d][1,2]oxathiole 2-oxide

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; N-chloro-succinimide; 2-methyl-but-2-ene; silver nitrate; Yield given. Multistep reaction; 1) aq. CH₃CN, -4 deg C, 10 min, 2) tBuOH, r.t., 20 h;
DOI:10.1007/BF00807309