(E)-2-cyano-3-(5-(4-((4-((E)-4-methoxystyryl)phenyl)(phenyl)-amino)phenyl)thiophen-2-yl)acrylic acid

Base Information

Chemical Name:(E)-2-cyano-3-(5-(4-((4-((E)-4-methoxystyryl)phenyl)(phenyl)-amino)phenyl)thiophen-2-yl)acrylic acid
CAS No.:1402346-64-8
Molecular Formula:C₃₅H₂₆N₂O₃S
Molecular Weight:554.669
Hs Code.:

Synonyms:(E)-2-cyano-3-(5-(4-((4-((E)-4-methoxystyryl)phenyl)(phenyl)-amino)phenyl)thiophen-2-yl)acrylic acid

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Chemical Property of (E)-2-cyano-3-(5-(4-((4-((E)-4-methoxystyryl)phenyl)(phenyl)-amino)phenyl)thiophen-2-yl)acrylic acid

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Technology Process of (E)-2-cyano-3-(5-(4-((4-((E)-4-methoxystyryl)phenyl)(phenyl)-amino)phenyl)thiophen-2-yl)acrylic acid

There total 2 articles about (E)-2-cyano-3-(5-(4-((4-((E)-4-methoxystyryl)phenyl)(phenyl)-amino)phenyl)thiophen-2-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1402346-60-4
(E)-5-(4-((4-(4-methoxystyryl)phenyl)(phenyl)amino)phenyl)thiophene-2-carbaldehyde

: 372-09-8
cyanoacetic acid

: 1402346-64-8
(E)-2-cyano-3-(5-(4-((4-((E)-4-methoxystyryl)phenyl)(phenyl)-amino)phenyl)thiophen-2-yl)acrylic acid

Guidance literature:: With piperidine; In acetonitrile; at 92 ℃; for 6h; Inert atmosphere;
DOI:10.1039/c2nj40374a

Reference yield:

: 1145-93-3
diethyl 4-methoxybenzylphosphonate

: 1402346-64-8
(E)-2-cyano-3-(5-(4-((4-((E)-4-methoxystyryl)phenyl)(phenyl)-amino)phenyl)thiophen-2-yl)acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / 8.17 h / 0 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / 12 h / 80 °C / Inert atmosphere

3: piperidine / acetonitrile / 6 h / 92 °C / Inert atmosphere

With piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate; potassium carbonate; In tetrahydrofuran; water; acetonitrile; 1: |Horner-Wadsworth-Emmons Olefination / 2: |Suzuki Coupling;
DOI:10.1039/c2nj40374a