2-bromo-3-[4-(methylsulfonyl)phenyl]-5-trifluoromethyl-pyridine

Base Information

• Chemical Name: 2-bromo-3-[4-(methylsulfonyl)phenyl]-5-trifluoromethyl-pyridine
• CAS No.: 202409-76-5
• Molecular Formula: C₁₃H₉BrF₃NO₂S
• Molecular Weight: 380.185
• Mol file: 202409-76-5.mol

Synonyms:2-bromo-3-[4-(methylsulfonyl)phenyl]-5-trifluoromethyl-pyridine

Chemical Property of 2-bromo-3-[4-(methylsulfonyl)phenyl]-5-trifluoromethyl-pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-bromo-3-[4-(methylsulfonyl)phenyl]-5-trifluoromethyl-pyridine

There total 5 articles about 2-bromo-3-[4-(methylsulfonyl)phenyl]-5-trifluoromethyl-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-amino-3-[4-(methylsulfonyl)phenyl]-5-trifluoromethyl-pyridine (202409-74-3) → 2-bromo-3-[4-(methylsulfonyl)phenyl]-5-trifluoromethyl-pyridine (202409-76-5)

Guidance literature:

With hydrogen bromide; bromine; sodium nitrite; at 0 - 25 ℃;

DOI:10.1016/S0960-894X(99)00264-4

Reference yield:

2-amino-5-trifluoromethylpyridine (74784-70-6) → 2-bromo-3-[4-(methylsulfonyl)phenyl]-5-trifluoromethyl-pyridine (202409-76-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / Br₂, AcOH / 25 °C

2: 93 percent / Pd(Ph₃P)4, 2N NaHCO₃ / ethanol; benzene / Heating

3: 90 percent / OsO₄, NMO / acetone; H₂O

4: 67 percent / NaNO₂, 40 percent aq. HBr, Br₂ / 0 - 25 °C

With osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-methyl-2-indolinone; hydrogen bromide; bromine; sodium hydrogencarbonate; acetic acid; sodium nitrite; In ethanol; water; acetone; benzene;

DOI:10.1016/S0960-894X(99)00264-4

Reference yield:

(4-thiomethoxyphenyl)boronic acid (98546-51-1) → 2-bromo-3-[4-(methylsulfonyl)phenyl]-5-trifluoromethyl-pyridine (202409-76-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / Pd(Ph₃P)4, 2N NaHCO₃ / ethanol; benzene / Heating

2: 90 percent / OsO₄, NMO / acetone; H₂O

3: 67 percent / NaNO₂, 40 percent aq. HBr, Br₂ / 0 - 25 °C

With osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-methyl-2-indolinone; hydrogen bromide; bromine; sodium hydrogencarbonate; sodium nitrite; In ethanol; water; acetone; benzene;

DOI:10.1016/S0960-894X(99)00264-4

upstream raw materials:

2-amino-3-[4-(methylsulfonyl)phenyl]-5-trifluoromethyl-pyridine

(4-thiomethoxyphenyl)boronic acid

2-amino-5-trifluoromethylpyridine

3-bromo-5-trifluoromethyl-pyridin-2-ylamine

Downstream raw materials:

2-(3-Chlorophenyl)-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl-pyridine