2,5-Dimethyl-4-hydroxybenzonitrile

Base Information

• Chemical Name: 2,5-Dimethyl-4-hydroxybenzonitrile
• CAS No.: 85223-94-5
• Molecular Formula: C9H9 N O
• Molecular Weight: 147.177
• Hs Code.: 2926909090
• Mol file: 85223-94-5.mol

Synonyms:4-hydroxy-2,5-dimethylbenzonitrile;

Chemical Property of 2,5-Dimethyl-4-hydroxybenzonitrile

Chemical Property:

• Vapor Pressure: 0.000317mmHg at 25°C
• Boiling Point: 311°C at 760 mmHg
• Flash Point: 141.9°C
• PSA: 44.02000
• Density: 1.13
• LogP: 1.88068
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxy-2,5-dimethylbenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-Dimethyl-4-hydroxybenzonitrile

There total 3 articles about 2,5-Dimethyl-4-hydroxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

4-iodo-2,5-dimethyl-phenol (114971-53-8) + copper(l) cyanide → 4-hydroxy-2,5-dimethylbenzonitrile (85223-94-5)

Guidance literature:

4-iodo-2,5-dimethyl-phenol; copper(l) cyanide; In N,N-dimethyl-formamide; for 6h; Reflux;

With ethylenediaminetetraacetic acid; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Reflux;

DOI:10.1155/2015/620938

Reference yield:

2,5-Dimethylphenol (95-87-4) → 4-hydroxy-2,5-dimethylbenzonitrile (85223-94-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium iodide; sodium hydroxide; sodium hypochlorite / methanol / 2 h / 0 - 4 °C

2.1: N,N-dimethyl-formamide / 6 h / Reflux

2.2: 24 h / 20 °C / Reflux

With sodium hypochlorite; sodium iodide; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1155/2015/620938

Reference yield:

2,2,2-trichloro-1-(4-hydroxy-2,5-dimethyl-phenyl)-ethanone-imine → 4-hydroxy-2,5-dimethylbenzonitrile (85223-94-5)

Guidance literature:

With sodium hydroxide;

upstream raw materials:

4-iodo-2,5-dimethyl-phenol

2,5-Dimethylphenol