3-{2-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile

Base Information

Chemical Name:3-{2-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile
CAS No.:1232068-48-2
Molecular Formula:C₂₁H₁₄ClN₃O₂S
Molecular Weight:407.88
Hs Code.:

Synonyms:3-{2-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile

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Chemical Property of 3-{2-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile

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Technology Process of 3-{2-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile

There total 4 articles about 3-{2-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1704-79-6
imidazolidin-4-one

: 1232069-23-6
5-(3-Chlorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylic acid

: 1232068-48-2
3-{2-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 150255-96-2
(3‐cyanophenyl)boronic acid

: 1232068-48-2
3-{2-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / palladium diacetate; XPhos / 1,2-dimethoxyethane / 3 h / 50 °C / Inert atmosphere

2: water; lithium hydroxide / 1,4-dioxane / 2 h / 50 °C

3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; palladium diacetate; XPhos; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane;

Reference yield:

: 1232068-90-4
Ethyl 4-bromo-5-(3-chlorophenyl)thiophene-2-carboxylate

: 1232068-48-2
3-{2-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / palladium diacetate; XPhos / 1,2-dimethoxyethane / 3 h / 50 °C / Inert atmosphere

2: water; lithium hydroxide / 1,4-dioxane / 2 h / 50 °C

3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; palladium diacetate; XPhos; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane;