N-((3-(3,4-dichlorophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-6-yl)methyl)-1-ethyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

Base Information

Chemical Name:N-((3-(3,4-dichlorophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-6-yl)methyl)-1-ethyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide
CAS No.:1429343-45-2
Molecular Formula:C₂₁H₂₂Cl₂N₄O₃
Molecular Weight:449.337
Hs Code.:

Synonyms:N-((3-(3,4-dichlorophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-6-yl)methyl)-1-ethyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

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Chemical Property of N-((3-(3,4-dichlorophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-6-yl)methyl)-1-ethyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

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Technology Process of N-((3-(3,4-dichlorophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-6-yl)methyl)-1-ethyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

There total 11 articles about N-((3-(3,4-dichlorophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-6-yl)methyl)-1-ethyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1429343-37-2
N-((3-(3,4-dichlorophenyl)imidazo[1,5-a]pyridin-6-yl)methyl)-1-ethyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

: 1429343-45-2
N-((3-(3,4-dichlorophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-6-yl)methyl)-1-ethyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; for 2h; Inert atmosphere;

Reference yield:

: 173999-23-0
C-(5-bromo-pyridin-2-yl)-methylamine

: 1429343-45-2
N-((3-(3,4-dichlorophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-6-yl)methyl)-1-ethyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

2: pyridine; trichlorophosphate / 1,2-dichloro-ethane / 1 h / Reflux

3: bis(tri-t-butylphosphine)palladium⁽⁰⁾; zinc / N,N-dimethyl-formamide / 0.5 h / 120 °C / Microwave irradiation; Inert atmosphere; Sealed tube

4: hydrogenchloride; hydrogen / methanol; water / 2 h / Inert atmosphere

5: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

6: boron tribromide-dimethyl sulfide complex / dichloromethane / 1 h / 20 °C

7: palladium 10% on activated carbon; hydrogen / methanol / 2 h / Inert atmosphere

With pyridine; hydrogenchloride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; boron tribromide-dimethyl sulfide complex; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; zinc; trichlorophosphate; In methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1429345-64-1
(3-(3,4-dichlorophenyl)imidazo[1,5-a]pyridin-6-yl)methanamine

: 1429343-45-2
N-((3-(3,4-dichlorophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-6-yl)methyl)-1-ethyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

2: boron tribromide-dimethyl sulfide complex / dichloromethane / 1 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / Inert atmosphere

With boron tribromide-dimethyl sulfide complex; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;