2-Aminomethyl-5-bromopyridine

Base Information

• Chemical Name: 2-Aminomethyl-5-bromopyridine
• CAS No.: 173999-23-0
• Molecular Formula: C6H7BrN2
• Molecular Weight: 187.039
• Hs Code.: 2933399090
• Mol file: 173999-23-0.mol

Synonyms:(5-Bromopyridin-2-yl)methanamine;[(5-Bromopyridin-2-yl)methyl]amine;

Chemical Property of 2-Aminomethyl-5-bromopyridine

Chemical Property:

• Vapor Pressure: 0.026mmHg at 25°C
• Refractive Index: 1.596
• Boiling Point: 247.2 ºC at 760 mmHg
• PKA: 8.31±0.39(Predicted)
• Flash Point: 103.3 ºC
• PSA: 38.91000
• Density: 1.574 g/cm³
• LogP: 2.00310
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(5-Bromopyridin-2-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Aminomethyl-5-bromopyridine

There total 6 articles about 2-Aminomethyl-5-bromopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-((5-bromopyridin-2-yl)methyl)isoindoline-1,3-dione (871728-43-7) → C-(5-bromo-pyridin-2-yl)-methylamine (173999-23-0)

Guidance literature:

With hydrazine hydrate; In ethanol; at 60 ℃; for 4h;

Reference yield: 80.0%

(5-bromopyridin-2-ylmethyl)carbamic acid tert-butyl ester (1188477-11-3) → C-(5-bromo-pyridin-2-yl)-methylamine (173999-23-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.bmc.2016.09.041

Reference yield:

2-Cyano-5-bromopyridine (97483-77-7) → C-(5-bromo-pyridin-2-yl)-methylamine (173999-23-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 14 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; trifluoroacetic acid; In methanol; dichloromethane;

upstream raw materials:

2-Cyano-5-bromopyridine

2,5-dibromopyridine

methylamine

(5-bromopyridin-2-ylmethyl)carbamic acid tert-butyl ester

Downstream raw materials:

6-bromo-3-(trifluoromethyl)imidazo[1,5-a]pyridine

(3-(3,4-dichlorophenyl)imidazo[1,5-a]pyridin-6-yl)methanamine

6-bromo-3-(3,4-dichlorophenyl)imidazo[1,5-a]pyridine

3-(3,4-dichlorophenyl)imidazo[1,5-a]pyridine-6-carbonitrile

Refernces

• 1、 -. "INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF". . . Retrieved 2019/09/30.
• 2、 -. "GLYCOSIDASE INHIBITORS". Page/Page column 115. . Retrieved 2017/09/15.