Technology Process of (5S)-ethyl 5-(diallylamino)-2-oxocyclohex-3-ene carboxylate
There total 11 articles about (5S)-ethyl 5-(diallylamino)-2-oxocyclohex-3-ene carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -40 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1021/jo400360j
- Guidance literature:
-
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -40 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydrogencarbonate / ethanol / 20 h / Inert atmosphere; Reflux
2.1: formic acid / 1 h / 80 °C / Inert atmosphere
3.1: triethylamine / tetrahydrofuran / 0.25 h / -10 °C / Inert atmosphere
4.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C / Inert atmosphere
5.1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 2 h / 0 °C / Inert atmosphere
6.1: 18-crown-6 ether; potassium hexamethylsilazane / toluene; tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere
6.2: 2 h / -78 °C / Inert atmosphere
7.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -40 °C / Inert atmosphere
With
sodium tetrahydroborate; formic acid; 18-crown-6 ether; sulfur trioxide pyridine complex; potassium hexamethylsilazane; sodium hydrogencarbonate; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; toluene;
6.1: |Horner-Wadsworth-Emmons Olefination / 6.2: |Horner-Wadsworth-Emmons Olefination / 7.1: |Dieckmann Condensation;
DOI:10.1021/jo400360j
