3-(4-(2-(1,3-dioxanyl))phenyl)-3-(trifluoromethyl)diazirine

Base Information

• Chemical Name: 3-(4-(2-(1,3-dioxanyl))phenyl)-3-(trifluoromethyl)diazirine
• CAS No.: 149183-55-1
• Molecular Formula: C₁₂H₁₁F₃N₂O₂
• Molecular Weight: 272.227
• Mol file: 149183-55-1.mol

Synonyms:3-(4-(2-(1,3-dioxanyl))phenyl)-3-(trifluoromethyl)diazirine

Chemical Property of 3-(4-(2-(1,3-dioxanyl))phenyl)-3-(trifluoromethyl)diazirine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-(2-(1,3-dioxanyl))phenyl)-3-(trifluoromethyl)diazirine

There total 4 articles about 3-(4-(2-(1,3-dioxanyl))phenyl)-3-(trifluoromethyl)diazirine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-(4-(2-(1,3-dioxanyl))phenyl)-3-(trifluoromethyl)diaziridine (149183-54-0) → 3-(4-(2-(1,3-dioxanyl))phenyl)-3-(trifluoromethyl)diazirine (149183-55-1)

Guidance literature:

With iodine; triethylamine; In methanol; for 1h;

DOI:10.1021/ja00062a009

Reference yield:

1-(4-(2-(1,3-dioxanyl))phenyl)-2,2,2-trifluoro-1-ethanone oxime → 3-(4-(2-(1,3-dioxanyl))phenyl)-3-(trifluoromethyl)diazirine (149183-55-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / triethylamine (TEA), 4-(dimethylamino)pyridine (DMAP) / CH₂Cl₂ / Ambient temperature

2: 70 percent / ammonia (liquid) / diethyl ether; CHCl₃ / 12 h / Ambient temperature

3: 73 percent / triethylamine (TEA), iodine / methanol / 1 h

With dmap; ammonia; iodine; triethylamine; In methanol; diethyl ether; dichloromethane; chloroform;

DOI:10.1021/ja00062a009

Reference yield:

1-(4-(2-(1,3-dioxanyl))phenyl)-2,2,2-trifluoro-1-ethanone O-(methylsulfonyl)oxime → 3-(4-(2-(1,3-dioxanyl))phenyl)-3-(trifluoromethyl)diazirine (149183-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / ammonia (liquid) / diethyl ether; CHCl₃ / 12 h / Ambient temperature

2: 73 percent / triethylamine (TEA), iodine / methanol / 1 h

With ammonia; iodine; triethylamine; In methanol; diethyl ether; chloroform;

DOI:10.1021/ja00062a009

upstream raw materials:

3-(4-(2-(1,3-dioxanyl))phenyl)-3-(trifluoromethyl)diaziridine

Downstream raw materials:

12-{(11-Carboxy-undecylsulfanyl)-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-methylsulfanyl}-dodecanoic acid

4-<3-trifluoromethyl-3H-diazirin-3-yl>benzaldehyde