2-[(2S,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl]ethyl 4-oxopentanoate

Base Information

• Chemical Name: 2-[(2S,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl]ethyl 4-oxopentanoate
• CAS No.: 1015230-44-0
• Molecular Formula: C₃₃H₃₈O₈
• Molecular Weight: 562.66
• Mol file: 1015230-44-0.mol

Synonyms:2-[(2S,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl]ethyl 4-oxopentanoate

Chemical Property of 2-[(2S,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl]ethyl 4-oxopentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2S,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl]ethyl 4-oxopentanoate

There total 8 articles about 2-[(2S,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl]ethyl 4-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Acetic acid 2-{(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-ethyl ester → 2-[(2S,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl]ethyl 4-oxopentanoate (1015230-44-0)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine

2: LiBH₄ / tetrahydrofuran / 6 h / 20 °C

With pyridine; lithium borohydride; In tetrahydrofuran;

DOI:10.1080/07328319808004683

Reference yield:

Acetic acid 2-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-ethyl ester → 2-[(2S,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl]ethyl 4-oxopentanoate (1015230-44-0)

Guidance literature:

Multi-step reaction with 3 steps

1: LiBH₄ / tetrahydrofuran / 6 h / 20 °C

With lithium borohydride; In tetrahydrofuran;

DOI:10.1080/07328319808004683

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 2-[(2S,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl]ethyl 4-oxopentanoate (1015230-44-0)

Guidance literature:

Multi-step reaction with 3 steps

2: LiBH₄

With lithium borohydride; 1: Substitution / 1: Condensation / 2: Reduction / 3: Acylation;

DOI:10.1080/07328319908044686

upstream raw materials:

4-Oxo-pentanoic acid 2-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-ethyl ester

levulinic anhydride

4,4'-dimethoxytrityl chloride

ethyl [2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]acetate