4-Oxo-pentanoic acid 2-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-ethyl ester

Base Information

• Chemical Name: 4-Oxo-pentanoic acid 2-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-ethyl ester
• CAS No.: 1015230-43-9
• Molecular Formula: C₃₉H₅₂O₈Si
• Molecular Weight: 676.923
• Mol file: 1015230-43-9.mol

Synonyms:

Chemical Property of 4-Oxo-pentanoic acid 2-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Oxo-pentanoic acid 2-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-ethyl ester

There total 4 articles about 4-Oxo-pentanoic acid 2-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 4-Oxo-pentanoic acid 2-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-ethyl ester (1015230-43-9)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine

2: LiBH₄ / tetrahydrofuran / 6 h / 20 °C

With pyridine; lithium borohydride; In tetrahydrofuran;

DOI:10.1080/07328319808004683

Reference yield:

Acetic acid 2-{(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-ethyl ester → 4-Oxo-pentanoic acid 2-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-ethyl ester (1015230-43-9)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine

2: LiBH₄ / tetrahydrofuran / 6 h / 20 °C

With pyridine; lithium borohydride; In tetrahydrofuran;

DOI:10.1080/07328319808004683

Reference yield:

Acetic acid 2-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-ethyl ester → 4-Oxo-pentanoic acid 2-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-ethyl ester (1015230-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1: LiBH₄ / tetrahydrofuran / 6 h / 20 °C

With lithium borohydride; In tetrahydrofuran;

DOI:10.1080/07328319808004683

upstream raw materials:

levulinic anhydride

5-(4,4'-dimethoxytrityl)-3-O-tert-butyldimethylsilyloxy-1,2-dideoxy-1-C-(2-hydroxyethyl)-β-D-erythro-pentofuranose

tert-butyldimethylsilyl chloride

Downstream raw materials:

2-[(2S,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl]ethyl 4-oxopentanoate