[4-(3-methoxy-phenyl)-but-3-ynyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [4-(3-methoxy-phenyl)-but-3-ynyl]-carbamic acid tert-butyl ester
• CAS No.: 905293-03-0
• Molecular Formula: C₁₆H₂₁NO₃
• Molecular Weight: 275.348
• Mol file: 905293-03-0.mol

Synonyms:[4-(3-methoxy-phenyl)-but-3-ynyl]-carbamic acid tert-butyl ester

Chemical Property of [4-(3-methoxy-phenyl)-but-3-ynyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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Technology Process of [4-(3-methoxy-phenyl)-but-3-ynyl]-carbamic acid tert-butyl ester

There total 1 articles about [4-(3-methoxy-phenyl)-but-3-ynyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxy-1-iodobenzene (766-85-8) + tert-butyl but-3-yn-1-ylcarbamate (149990-27-2) → [4-(3-methoxy-phenyl)-but-3-ynyl]-carbamic acid tert-butyl ester (905293-03-0)

Guidance literature:

With diethylamine; triphenylphosphine; palladium dichloride; copper(l) iodide; at 20 ℃;

DOI:10.1021/jm051134w

Reference yield: 96.0%

[4-(3-methoxy-phenyl)-but-3-ynyl]-carbamic acid tert-butyl ester (905293-03-0) + 4-methoxyphenylacetylen (768-60-5) → 4a-(3-methoxyphenyl)-3-(4-methoxyphenyl)-4a,5,6,7-tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazin-1-one

Guidance literature:

With (1,5-cyclooctadiene)dimethylplatinum(II); trifluorormethanesulfonic acid; In dichloromethane; at -10 ℃; Inert atmosphere;

DOI:10.1002/chem.201405776

Reference yield: 85.0%

[4-(3-methoxy-phenyl)-but-3-ynyl]-carbamic acid tert-butyl ester (905293-03-0) + 2-(hydroxy(phenyl)methyl)phenol (40473-50-5) → tert-butyl (3aR*,4R*,9aR*)-9a-(3-methoxyphenyl)-4-phenyl-2,3,3a,9a-tetrahydrochromeno[2,3-b]pyrrole-1(4H)-carboxylate

Guidance literature:

With [(1,1′-biphenyl-2-yl)di-tert-butylphosphine]gold(I) bis(trifluoromethanesulfonyl)imide; boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 15h; diastereoselective reaction; Molecular sieve; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201800679

upstream raw materials:

3-methoxy-1-iodobenzene

tert-butyl but-3-yn-1-ylcarbamate

Downstream raw materials:

[4-(3-methoxy-phenyl)-butyl]-carbamic acid tert-butyl ester