ethyl 2-[4-(4-{3,-[2-tert-butyl-4-(1-methyl-1H-pyrazol-5-yl)-1H-imidazol-5-yl]ureido}phenoxy)-6-methoxyquinolin-7-yloxy]acetate

Base Information

• Chemical Name: ethyl 2-[4-(4-{3,-[2-tert-butyl-4-(1-methyl-1H-pyrazol-5-yl)-1H-imidazol-5-yl]ureido}phenoxy)-6-methoxyquinolin-7-yloxy]acetate
• CAS No.: 1355346-75-6
• Molecular Formula: C₃₂H₃₅N₇O₆
• Molecular Weight: 613.673
• Mol file: 1355346-75-6.mol

Synonyms:ethyl 2-[4-(4-{3,-[2-tert-butyl-4-(1-methyl-1H-pyrazol-5-yl)-1H-imidazol-5-yl]ureido}phenoxy)-6-methoxyquinolin-7-yloxy]acetate

Chemical Property of ethyl 2-[4-(4-{3,-[2-tert-butyl-4-(1-methyl-1H-pyrazol-5-yl)-1H-imidazol-5-yl]ureido}phenoxy)-6-methoxyquinolin-7-yloxy]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-[4-(4-{3,-[2-tert-butyl-4-(1-methyl-1H-pyrazol-5-yl)-1H-imidazol-5-yl]ureido}phenoxy)-6-methoxyquinolin-7-yloxy]acetate

There total 3 articles about ethyl 2-[4-(4-{3,-[2-tert-butyl-4-(1-methyl-1H-pyrazol-5-yl)-1H-imidazol-5-yl]ureido}phenoxy)-6-methoxyquinolin-7-yloxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

2-tert-butyl-4-(1-methyl-1H-pyrazol-5-yl)-1H-imidazole-5-carboxylic acid (1355347-75-9) + ethyl 2-((4-(4-aminophenoxy)-6-methoxyquinolin-7-yl)oxy)acetate (1355031-17-2) → ethyl 2-[4-(4-{3,-[2-tert-butyl-4-(1-methyl-1H-pyrazol-5-yl)-1H-imidazol-5-yl]ureido}phenoxy)-6-methoxyquinolin-7-yloxy]acetate (1355346-75-6)

Guidance literature:

2-tert-butyl-4-(1-methyl-1H-pyrazol-5-yl)-1H-imidazole-5-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In chloroform; at 50 ℃; for 1h;

ethyl 2-((4-(4-aminophenoxy)-6-methoxyquinolin-7-yl)oxy)acetate; In chloroform; at 50 ℃;

Reference yield:

4-(7-benzyloxy-6-methoxyquinolin-4-yloxy)aniline (516526-32-2) → ethyl 2-[4-(4-{3,-[2-tert-butyl-4-(1-methyl-1H-pyrazol-5-yl)-1H-imidazol-5-yl]ureido}phenoxy)-6-methoxyquinolin-7-yloxy]acetate (1355346-75-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trifluoroacetic acid; methanesulfonic acid / 1.5 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 1 h / 20 °C

3.1: triethylamine; diphenyl phosphoryl azide / chloroform / 1 h / 50 °C

3.2: 50 °C

With methanesulfonic acid; diphenyl phosphoryl azide; sodium hydride; triethylamine; trifluoroacetic acid; In chloroform; N,N-dimethyl-formamide;

Reference yield:

4-(4-aminophenoxy)-6-methoxyquinolin-7-ol (1355031-15-0) → ethyl 2-[4-(4-{3,-[2-tert-butyl-4-(1-methyl-1H-pyrazol-5-yl)-1H-imidazol-5-yl]ureido}phenoxy)-6-methoxyquinolin-7-yloxy]acetate (1355346-75-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 1 h / 20 °C

2.1: triethylamine; diphenyl phosphoryl azide / chloroform / 1 h / 50 °C

2.2: 50 °C

With diphenyl phosphoryl azide; sodium hydride; triethylamine; In chloroform; N,N-dimethyl-formamide;

upstream raw materials:

2-tert-butyl-4-(1-methyl-1H-pyrazol-5-yl)-1H-imidazole-5-carboxylic acid

ethyl 2-((4-(4-aminophenoxy)-6-methoxyquinolin-7-yl)oxy)acetate

4-(7-benzyloxy-6-methoxyquinolin-4-yloxy)aniline

4-(4-aminophenoxy)-6-methoxyquinolin-7-ol

Downstream raw materials:

1-[2-tert-butyl-4-(1-methyl-1H-pyrazol-5-yl)-1H-imidazol-5-yl]-3-{4-[7-(2-hydroxyethoxy)-6-methoxyquinolin-4-yloxy]phenyl}urea