ethyl 2-((4-(4-aminophenoxy)-6-methoxyquinolin-7-yl)oxy)acetate

Base Information

• Chemical Name: ethyl 2-((4-(4-aminophenoxy)-6-methoxyquinolin-7-yl)oxy)acetate
• CAS No.: 1355031-17-2
• Molecular Formula: C₂₀H₂₀N₂O₅
• Molecular Weight: 368.389
• Mol file: 1355031-17-2.mol

Synonyms:ethyl 2-((4-(4-aminophenoxy)-6-methoxyquinolin-7-yl)oxy)acetate

Chemical Property of ethyl 2-((4-(4-aminophenoxy)-6-methoxyquinolin-7-yl)oxy)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-((4-(4-aminophenoxy)-6-methoxyquinolin-7-yl)oxy)acetate

There total 8 articles about ethyl 2-((4-(4-aminophenoxy)-6-methoxyquinolin-7-yl)oxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.2%

ethyl 2-((6-methoxy-4-(4-nitrophenoxy)quinolin-7-yl)oxy)acetate → ethyl 2-((4-(4-aminophenoxy)-6-methoxyquinolin-7-yl)oxy)acetate (1355031-17-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 40 ℃; for 4h;

DOI:10.1016/j.ejmech.2020.112651

Reference yield: 25.0%

4-(4-aminophenoxy)-6-methoxyquinolin-7-ol (1355031-15-0) + ethyl bromoacetate (105-36-2) → ethyl 2-((4-(4-aminophenoxy)-6-methoxyquinolin-7-yl)oxy)acetate (1355031-17-2)

Guidance literature:

4-(4-aminophenoxy)-6-methoxyquinolin-7-ol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

ethyl bromoacetate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

4-(7-benzyloxy-6-methoxyquinolin-4-yloxy)aniline (516526-32-2) → ethyl 2-((4-(4-aminophenoxy)-6-methoxyquinolin-7-yl)oxy)acetate (1355031-17-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid; methanesulfonic acid / 1.5 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 1 h / 20 °C

With methanesulfonic acid; sodium hydride; trifluoroacetic acid; In N,N-dimethyl-formamide;

upstream raw materials:

4-(4-aminophenoxy)-6-methoxyquinolin-7-ol

ethyl bromoacetate

4-(7-benzyloxy-6-methoxyquinolin-4-yloxy)aniline

1-(3-methoxy-4-hydroxyphenyl)ethanone

Downstream raw materials:

ethyl 2-[4-(4-{3,-[2-tert-butyl-4-(1-methyl-1H-pyrazol-5-yl)-1H-imidazol-5-yl]ureido}phenoxy)-6-methoxyquinolin-7-yloxy]acetate

1-[2-tert-butyl-4-(1-methyl-1H-pyrazol-5-yl)-1H-imidazol-5-yl]-3-{4-[7-(2-hydroxyethoxy)-6-methoxyquinolin-4-yloxy]phenyl}urea