2-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)-1-(morpholin-4-yl)ethanone

Base Information

Chemical Name:2-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)-1-(morpholin-4-yl)ethanone
CAS No.:1431533-67-3
Molecular Formula:C₂₃H₂₇FN₂O₅
Molecular Weight:430.476
Hs Code.:

Synonyms:2-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)-1-(morpholin-4-yl)ethanone

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Chemical Property of 2-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)-1-(morpholin-4-yl)ethanone

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Technology Process of 2-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)-1-(morpholin-4-yl)ethanone

There total 8 articles about 2-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)-1-(morpholin-4-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1440-61-5
N-chloroacetylmorpholine

: 1431533-66-2
2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-ol

: 1431533-67-3
2-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)-1-(morpholin-4-yl)ethanone

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; for 1h; Inert atmosphere;

Reference yield:

: 350-29-8
3-fluoro-4-hydroxybenzoic acid

: 1431533-67-3
2-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)-1-(morpholin-4-yl)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / methanol / 24 h / Reflux

1.2: 1 h / 70 °C

1.3: 2 h / 50 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran; water / 0.5 h / 20 °C

3.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 1 h / Inert atmosphere

3.2: 0.5 h / 60 °C

4.1: hydrogenchloride / methanol; tetrahydrofuran / 1 h / 70 °C

4.2: 0.33 h / 20 °C

5.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; sulfuric acid; potassium tert-butylate; sulfur trioxide pyridine complex; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; water; dimethyl sulfoxide;

Reference yield:

: 1021144-38-6
4-(cyclopropylmethoxy)-3-fluorobenzoic acid

: 1431533-67-3
2-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)-1-(morpholin-4-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran; water / 0.5 h / 20 °C

2.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 1 h / Inert atmosphere

2.2: 0.5 h / 60 °C

3.1: hydrogenchloride / methanol; tetrahydrofuran / 1 h / 70 °C

3.2: 0.33 h / 20 °C

4.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; potassium tert-butylate; sulfur trioxide pyridine complex; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; water; dimethyl sulfoxide;