benzyl N-{2-[(9H-fluoren-9-yl)methoxycarbonyl]aminoethyl}glycinate hydrochloride

Base Information

• Chemical Name: benzyl N-{2-[(9H-fluoren-9-yl)methoxycarbonyl]aminoethyl}glycinate hydrochloride
• CAS No.: 511534-93-3
• Molecular Formula: C₂₆H₂₆N₂O₄*ClH
• Molecular Weight: 466.964
• Mol file: 511534-93-3.mol

Synonyms:benzyl N-{2-[(9H-fluoren-9-yl)methoxycarbonyl]aminoethyl}glycinate hydrochloride

Chemical Property of benzyl N-{2-[(9H-fluoren-9-yl)methoxycarbonyl]aminoethyl}glycinate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl N-{2-[(9H-fluoren-9-yl)methoxycarbonyl]aminoethyl}glycinate hydrochloride

There total 1 articles about benzyl N-{2-[(9H-fluoren-9-yl)methoxycarbonyl]aminoethyl}glycinate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl N-[2-(N-9-fluorenylmethoxycarbonyl)aminoethyl]glycinate hydrochloride (169396-88-7) + benzyl alcohol (100-51-6,185532-71-2) → benzyl N-{2-[(9H-fluoren-9-yl)methoxycarbonyl]aminoethyl}glycinate hydrochloride (511534-93-3)

Guidance literature:

tert-butyl N-[2-(N-9-fluorenylmethoxycarbonyl)aminoethyl]glycinate hydrochloride; With toluene-4-sulfonic acid; In toluene; at 80 ℃; for 1h;

benzyl alcohol; In toluene; for 2h; Reflux; Dean-Stark;

With hydrogenchloride; In water; ethyl acetate;

DOI:10.1016/j.bmcl.2017.06.015

Reference yield: 94.0%

benzyl N-{2-[(9H-fluoren-9-yl)methoxycarbonyl]aminoethyl}glycinate hydrochloride (511534-93-3) + 2-{2-[(4-methoxy-2-methylbenzyl)thio]-4-oxopyrimidin-1(4H)-yl}acetic acid → benzyl N-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-N-(2-{2-[(4-methoxy-2-methylbenzyl)thio]-4-oxopyrimidin-1(4H)-yl}acetyl)glycinate

Guidance literature:

2-{2-[(4-methoxy-2-methylbenzyl)thio]-4-oxopyrimidin-1(4H)-yl}acetic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.0333333h;

benzyl N-{2-[(9H-fluoren-9-yl)methoxycarbonyl]aminoethyl}glycinate hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2017.06.015

Reference yield: 94.0%

benzyl N-{2-[(9H-fluoren-9-yl)methoxycarbonyl]aminoethyl}glycinate hydrochloride (511534-93-3) + N2,N2,N6,N6-tetra(Boc)-2,6-diaminopurin-9-ylacetic acid (1354832-42-0) → C53H64N8O13

Guidance literature:

With N-ethyl-N,N-diisopropylamine; ((3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V); In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

DOI:10.1016/j.bmcl.2017.06.015

upstream raw materials:

tert-butyl N-[2-(N-9-fluorenylmethoxycarbonyl)aminoethyl]glycinate hydrochloride

benzyl alcohol