Technology Process of (S)-1-(N-diphenylmethyl)amino-1-cyano-2-methyl-2-propene
There total 2 articles about (S)-1-(N-diphenylmethyl)amino-1-cyano-2-methyl-2-propene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Benzhydryl-[2-methyl-prop-2-en-(E)-ylidene]-amine;
With
C31H43N3O8;
titanium(IV) isopropylate;
In
toluene;
at 22 ℃;
for 0.166667h;
trimethylsilyl cyanide;
With
butan-1-ol;
In
toluene;
at -20 ℃;
for 14h;
Further stages. Title compound not separated from byproducts.;
DOI:10.1021/ja994121e
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: MgSO4 / benzene / 8 h / 22 °C
2.1: 2-hydroxy-1-napthaldehyde-t-Leu-Thr(t-Bu)-Gly(OMe) / Ti(Oi-Pr)4 / toluene / 0.17 h / 22 °C
2.2: n-BuOH / toluene / 14 h / -20 °C
With
C31H43N3O8; magnesium sulfate;
titanium(IV) isopropylate;
In
toluene; benzene;
1.1: Condensation / 2.1: Condensation / 2.2: Condensation;
DOI:10.1021/ja994121e
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: HOAc / methanol / 0.5 h / 22 °C
1.2: HCl / 5.5 h / 22 °C
2.1: TFA; Et3SiH / 4 h / 80 °C
3.1: HCl / methanol / -40 - 22 °C
4.1: 67 percent / NaOH / dioxane; H2O / 1 h / pH 10
5.1: 94 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C
With
hydrogenchloride; triethylsilane; sodium hydroxide; hydrogen; acetic acid; trifluoroacetic acid;
palladium on activated charcoal;
In
1,4-dioxane; methanol; water; ethyl acetate;
1.1: Hydrolysis / 1.2: Condensation / 2.1: acidolysis / 3.1: Hydrolysis / 4.1: Acylation / 5.1: Catalytic hydrogenation;
DOI:10.1021/ja994121e
