N₂-5-[4-(dimethylamino)phenyl]-4,5-dihydro-1H-3-pyrazolyl-4-phenyl-1,3-thiazol-2-amine

Base Information

• Chemical Name: N₂-5-[4-(dimethylamino)phenyl]-4,5-dihydro-1H-3-pyrazolyl-4-phenyl-1,3-thiazol-2-amine
• CAS No.: 1451144-52-7
• Molecular Formula: C₂₀H₂₁N₅S
• Molecular Weight: 363.486

Synonyms:N₂-5-[4-(dimethylamino)phenyl]-4,5-dihydro-1H-3-pyrazolyl-4-phenyl-1,3-thiazol-2-amine

Chemical Property of N₂-5-[4-(dimethylamino)phenyl]-4,5-dihydro-1H-3-pyrazolyl-4-phenyl-1,3-thiazol-2-amine

Chemical Property:

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Technology Process of N₂-5-[4-(dimethylamino)phenyl]-4,5-dihydro-1H-3-pyrazolyl-4-phenyl-1,3-thiazol-2-amine

There total 3 articles about N₂-5-[4-(dimethylamino)phenyl]-4,5-dihydro-1H-3-pyrazolyl-4-phenyl-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-(4-dimethylamino-phenyl)-N-(4-phenyl-thiazol-2-yl)-acrylamide (74675-94-8) → N2-5-[4-(dimethylamino)phenyl]-4,5-dihydro-1H-3-pyrazolyl-4-phenyl-1,3-thiazol-2-amine (1451144-52-7)

Guidance literature:

With aluminum oxide; hydrazine hydrate; In ethanol; acetone; for 0.116667h; Microwave irradiation;

Reference yield:

2-acetamide-4-phenyl-1,3-thiazole (5039-09-8) → N2-5-[4-(dimethylamino)phenyl]-4,5-dihydro-1H-3-pyrazolyl-4-phenyl-1,3-thiazol-2-amine (1451144-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol

2: hydrazine hydrate; aluminum oxide / ethanol; acetone / 0.12 h / Microwave irradiation

With aluminum oxide; hydrazine hydrate; sodium hydroxide; In ethanol; acetone;

Reference yield:

4-dimethylamino-benzaldehyde (100-10-7) → N2-5-[4-(dimethylamino)phenyl]-4,5-dihydro-1H-3-pyrazolyl-4-phenyl-1,3-thiazol-2-amine (1451144-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol

2: hydrazine hydrate; aluminum oxide / ethanol; acetone / 0.12 h / Microwave irradiation

With aluminum oxide; hydrazine hydrate; sodium hydroxide; In ethanol; acetone;

upstream raw materials:

3-(4-dimethylamino-phenyl)-N-(4-phenyl-thiazol-2-yl)-acrylamide

2-acetamide-4-phenyl-1,3-thiazole

4-dimethylamino-benzaldehyde

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