5039-09-8

Basic information

• Product Name: N-(4-phenyl-1,3-thiazol-2-yl)acetamide
• Synonyms: acetamide, N-(4-phenyl-2-thiazolyl)-
• CAS NO: 5039-09-8
• Molecular Formula: C₁₁H₁₀N₂OS
• Molecular Weight: 218.2749
• Mol File: 5039-09-8.mol
• Article Data: 12

Chemical Properties

• Density: 1.28g/cm³
• Refractive Index: 1.642
• CAS DataBase Reference: N-(4-phenyl-1,3-thiazol-2-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-phenyl-1,3-thiazol-2-yl)acetamide(5039-09-8)
• EPA Substance Registry System: N-(4-phenyl-1,3-thiazol-2-yl)acetamide(5039-09-8)

Safety Data

• Hazardous Substances Data: 5039-09-8(Hazardous Substances Data)

Usage

General Description

N-(4-phenyl-1,3-thiazol-2-yl)acetamide is a compound with the chemical formula C11H10N2OS. It is a derivative of thiazole and acetamide, and is commonly used in organic synthesis and pharmaceutical research. N-(4-phenyl-1,3-thiazol-2-yl)acetamide has potential applications in the pharmaceutical industry due to its antibacterial, antifungal, and antiviral properties. It also shows potential as an anti-inflammatory and analgesic agent. N-(4-phenyl-1,3-thiazol-2-yl)acetamide has a thiazole ring and a phenyl group, which contribute to its biological activity and potential therapeutic uses. Its unique chemical structure and properties make it an interesting target for further research and development in drug discovery and medicinal chemistry.

Upstream product

• 2010-06-2 2-Amino-4-phenylthiazole 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 127-09-3 sodium acetate 
• 19433-17-1 acetophenone O-acetyloxime 
• 70-11-1 α-bromoacetophenone 
• 87273-74-3 N-(4-phenylthiazol-2-yl)-3-aminocrotonamide 
• 87273-73-2 6-Methyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-[1,3]oxazin-4-one 
• 87273-75-4 3‐oxo‐N‐(4‐phenylthiazol‐2yl)butanamide 

Downstream Products

• 99970-50-0 N-(4-phenyl-5-thiocyanato-thiazol-2-yl)-acetamide 
• 4588-03-8 N-(5-diethylaminomethyl-4-phenyl-thiazol-2-yl)-acetamide 
• 62263-07-4 4-(2-acetylamino-thiazol-4-yl)-benzenesulfonyl chloride 
• 4678-82-4 N-(4-phenyl-5-piperidin-1-ylmethyl-thiazol-2-yl)-acetamide 
• 4588-10-7 1,4-bis-(2-acetylamino-4-phenyl-thiazol-5-ylmethyl)-piperazine 
• 4588-08-3 N-(5-benzoimidazol-1-ylmethyl-4-phenyl-thiazol-2-yl)-acetamide 
• 4588-09-4 N-[5-(2-methyl-benzoimidazol-1-ylmethyl)-4-phenyl-thiazol-2-yl]-acetamide 
• 73034-88-5 3-(2-acetylamino-thiazol-4-yl)-benzenesulfonamide 
• 1451144-57-2 C₁₉H₁₈N₄S 
• 1451144-58-3 C₁₈H₁₅ClN₄S 
• 1451144-59-4 C₁₈H₁₅ClN₄S 
• 1451144-60-7 N-(1,5-diphenyl-4,5-dihydro-1H-3-pyrazolyl)-N-(4-phenyl-1,3-thiazol-2-yl)amine 
• 1451144-61-8 N-[5-(2-nitrophenyl)-1-phenyl-4,5-dihydro-1H-3-pyrazolyl]-N-(4-phenyl-1,3-thiazol-2-yl)amine 
• 1451144-62-9 N₂-5-[4-(dimethylamino)phenyl]-1-phenyl-4,5-dihydro-1H-3-pyrazolyl-4-phenyl-1,3-thiazol-2-amine 

Relevant articles and documents

NOVEL COMPOUNDS

The present invention relates to novel compounds of formula (I) and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or ubiquitin spec

2-amino-4-arylthiazole derivatives as anti-giardial agents: Synthesis, biological evaluation and QSAR studies

A series of seven 2-amino-4-arylthiazoles were prepared following Hantzsch's modified method under microwave irradiation. A set of 50 derivatives was obtained and the in vitro activity against Giardia intestinalis was evaluated. The results on the biological activity revealed that, in general, the N-(5-bromo-4-aryl-thiazol-2-yl)-acetamide scaffold showed high bioactivity. In particular, compounds 6e (IC50= 0.39 μM) and 6b (IC50= 0.87 μM) were found to be more potent than the positive control metronidazole. Citoxicity and acute toxicity tests performed showed low toxicity and high selectivity of the most active compounds (6e SI = 139, 6b SI = 52.3). A QSAR analysis was applied to a data set of 37 obtained 2-amino-4-arylthiazoles derivatives and the best model described a strongly correlation between the anti-giardiasic activity and molecular descriptors as E2M, RDF115m, F10, MATS6v, and Hypnotic-80, with high statistical quality. This finding indicates that N-substituted aminothiazole scaffold should be investigated for the development of highly selective anti-giardial agent.

Preparation, antimicrobial activity, and toxicity of 2-amino-4-arylthiazole derivatives

Seven 2-amino-4-aryl-1,3-thiazoles (1a-g) and their corresponding 2-aminoacetyl (2a-g) and 2-aminoacetyl-5-bromo (3a-g) derivatives were synthesized and tested in vitro against 11 reference strains, three Gram-positive and four Gram-negative bacteria, two yeasts, and two moulds. Toxicity of the compounds was also evaluated using the brine shrimp test. Compounds 1a, 1b, 1e-g, and 3b showed moderate antimicrobial activity at different concentrations. The results indicated that acetylation of the amino group and bromination at position 5 of the thiazole moiety cause lost of activity. Compounds 1a, 1e, and 1f showed toxicity to brine shrimp nauplii below 10 ppm. Most other compounds showed moderate toxicity, LD50 above 100 ppm. Structures of all compounds were confirmed by NMR and MS data.