3-[2,4-bis(tert-butyldimethylsilanyloxy)-6-methylbenzyl]dihydrofuran-2-one

Base Information

Chemical Name:3-[2,4-bis(tert-butyldimethylsilanyloxy)-6-methylbenzyl]dihydrofuran-2-one
CAS No.:1426384-74-8
Molecular Formula:C₂₄H₄₂O₄Si₂
Molecular Weight:450.766
Hs Code.:

Synonyms:3-[2,4-bis(tert-butyldimethylsilanyloxy)-6-methylbenzyl]dihydrofuran-2-one

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Chemical Property of 3-[2,4-bis(tert-butyldimethylsilanyloxy)-6-methylbenzyl]dihydrofuran-2-one

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Technology Process of 3-[2,4-bis(tert-butyldimethylsilanyloxy)-6-methylbenzyl]dihydrofuran-2-one

There total 3 articles about 3-[2,4-bis(tert-butyldimethylsilanyloxy)-6-methylbenzyl]dihydrofuran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: C₁₂H₁₄O₄

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1426384-74-8
3-[2,4-bis(tert-butyldimethylsilanyloxy)-6-methylbenzyl]dihydrofuran-2-one

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 0.24h; Inert atmosphere;
DOI:10.1021/jo302545n

Reference yield:

: 7149-90-8
2,4-dimethoxy-6-methyl-benzaldehyde

: 1426384-74-8
3-[2,4-bis(tert-butyldimethylsilanyloxy)-6-methylbenzyl]dihydrofuran-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: lithium diisopropyl amide / tetrahydrofuran / 7 h / -78 - 0 °C / Inert atmosphere

2: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 2 h / 0 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 25 h / 0 - 20 °C / Inert atmosphere

4: 1H-imidazole / N,N-dimethyl-formamide / 0.24 h / 20 °C / Inert atmosphere

With 1H-imidazole; triethylsilane; boron trifluoride diethyl etherate; boron tribromide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: |Aldol Condensation;
DOI:10.1021/jo302545n

Reference yield:

: 1426384-72-6
3-[(2,4-dimethoxy-6-methylphenyl)hydroxymethyl]dihydrofuran-2-one

: 1426384-74-8
3-[2,4-bis(tert-butyldimethylsilanyloxy)-6-methylbenzyl]dihydrofuran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 2 h / 0 °C / Inert atmosphere

2: boron tribromide / dichloromethane / 25 h / 0 - 20 °C / Inert atmosphere

3: 1H-imidazole / N,N-dimethyl-formamide / 0.24 h / 20 °C / Inert atmosphere

With 1H-imidazole; triethylsilane; boron trifluoride diethyl etherate; boron tribromide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo302545n