7α-(4-benzyloxyphenyl)androst-5-ene-7β,17β-diol-3β-yl acetate

Base Information

• Chemical Name: 7α-(4-benzyloxyphenyl)androst-5-ene-7β,17β-diol-3β-yl acetate
• CAS No.: 137196-52-2
• Molecular Formula: C₃₄H₄₂O₅
• Molecular Weight: 530.704
• Mol file: 137196-52-2.mol

Synonyms:7α-(4-benzyloxyphenyl)androst-5-ene-7β,17β-diol-3β-yl acetate

Chemical Property of 7α-(4-benzyloxyphenyl)androst-5-ene-7β,17β-diol-3β-yl acetate

Chemical Property:

Purity/Quality:

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Technology Process of 7α-(4-benzyloxyphenyl)androst-5-ene-7β,17β-diol-3β-yl acetate

There total 1 articles about 7α-(4-benzyloxyphenyl)androst-5-ene-7β,17β-diol-3β-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-benzyloxyphenylbromide (6793-92-6) + 3β, 17β-diacetoxyandrost-5-ene-7-one (13209-60-4) → 7α-(4-benzyloxyphenyl)androst-5-ene-7β,17β-diol-3β-yl acetate (137196-52-2) + 7β-(4-benzyloxyphenyl)androst-5-ene-3β,7α,17β-triol (137196-51-1) + 7α-(4-benzyloxyphenyl)androst-5-ene-3β,7β,17β-triol (137196-50-0)

Guidance literature:

With 1,1-Dibromoethane; magnesium; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, reflux, 1.5 h, 2.) THF, reflux, 10 h;

DOI:10.1016/0039-128X(91)90005-G

Reference yield: 66.6%

7α-(4-benzyloxyphenyl)androst-5-ene-7β,17β-diol-3β-yl acetate (137196-52-2) → Acetic acid (3S,7R,8R,9S,10R,13S,14S)-7-(4-benzyloxy-phenyl)-7-hydroxy-10,13-dimethyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:

With jones reagent; In acetone; for 0.0833333h;

DOI:10.1016/0039-128X(91)90005-G

upstream raw materials:

p-benzyloxyphenylbromide

3β, 17β-diacetoxyandrost-5-ene-7-one