(S)-3-(naphthalen-2-yl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Base Information

• Chemical Name: (S)-3-(naphthalen-2-yl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide
• CAS No.: 1582806-84-5
• Molecular Formula: C₂₈H₁₅F₇N₂O₃
• Molecular Weight: 560.428
• Mol file: 1582806-84-5.mol

Synonyms:(S)-3-(naphthalen-2-yl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Chemical Property of (S)-3-(naphthalen-2-yl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-(naphthalen-2-yl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

There total 6 articles about (S)-3-(naphthalen-2-yl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-iodonaphthalene (612-55-5) + (S)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide (1582806-46-9) → (S)-3-(naphthalen-2-yl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide (1582806-84-5) + C38H21F7N2O3

Guidance literature:

With α-picoline; palladium(II) trifluoroacetate; silver carbonate; trifluoroacetic acid; In 1,2-dichloro-ethane; at 100 ℃; for 20h; Sealed tube;

Reference yield: 91.0%

2-iodonaphthalene (612-55-5) + (S)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide (1582806-46-9) → (S)-3-(naphthalen-2-yl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide (1582806-84-5)

Guidance literature:

With α-picoline; palladium(II) trifluoroacetate; silver carbonate; trifluoroacetic acid; In 1,2-dichloro-ethane; at 100 ℃; for 20h;

DOI:10.1126/science.1249198

Reference yield:

N-ethoxycarbonylphthalimide (22509-74-6) → (S)-3-(naphthalen-2-yl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide (1582806-84-5) + C38H21F7N2O3

Guidance literature:

Multi-step reaction with 4 steps

1: sodium carbonate / water / 3 h / 20 °C

2: thionyl chloride; N,N-dimethyl-formamide / toluene / 3 h / 80 °C

3: toluene / 12 h / Reflux

4: palladium(II) trifluoroacetate; silver carbonate; trifluoroacetic acid; α-picoline / 1,2-dichloro-ethane / 20 h / 100 °C / Sealed tube

With α-picoline; thionyl chloride; palladium(II) trifluoroacetate; sodium carbonate; N,N-dimethyl-formamide; silver carbonate; trifluoroacetic acid; In water; 1,2-dichloro-ethane; toluene;

upstream raw materials:

2-iodonaphthalene

(S)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

N-ethoxycarbonylphthalimide

phthalic anhydride