2-(2-{[(2S,5S)-2-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-5-methyl-1-piperidinyl]carbonyl}-6-methyl-3-pyridinyl)pyrimidine

Base Information

Chemical Name:2-(2-{[(2S,5S)-2-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-5-methyl-1-piperidinyl]carbonyl}-6-methyl-3-pyridinyl)pyrimidine
CAS No.:1268817-70-4
Molecular Formula:C₃₄H₄₀N₄O₂Si
Molecular Weight:564.803
Hs Code.:

Synonyms:2-(2-{[(2S,5S)-2-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-5-methyl-1-piperidinyl]carbonyl}-6-methyl-3-pyridinyl)pyrimidine

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Chemical Property of 2-(2-{[(2S,5S)-2-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-5-methyl-1-piperidinyl]carbonyl}-6-methyl-3-pyridinyl)pyrimidine

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Technology Process of 2-(2-{[(2S,5S)-2-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-5-methyl-1-piperidinyl]carbonyl}-6-methyl-3-pyridinyl)pyrimidine

There total 10 articles about 2-(2-{[(2S,5S)-2-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-5-methyl-1-piperidinyl]carbonyl}-6-methyl-3-pyridinyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.6%

: 1228188-18-8
6-methyl-3-(pyrimidin-2-yl)pyridine-2-carboxylic acid

: 1268817-69-1
(2S,5S)-2-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-5-methylpiperidine

: 1268817-70-4
2-(2-{[(2S,5S)-2-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-5-methyl-1-piperidinyl]carbonyl}-6-methyl-3-pyridinyl)pyrimidine

Guidance literature:: 6-methyl-3-(pyrimidin-2-yl)pyridine-2-carboxylic acid; (2S,5S)-2-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-5-methylpiperidine; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃;

Reference yield:

: 626-56-2,53152-98-0
3-Methylpiperidine

: 1268817-70-4
2-(2-{[(2S,5S)-2-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-5-methyl-1-piperidinyl]carbonyl}-6-methyl-3-pyridinyl)pyrimidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: diethyl ether; methanol / 0 °C / Inert atmosphere

2.1: sodium hydroxide; di-tert-butyl dicarbonate / water; tetrahydrofuran / 1 h / 0 - 20 °C

3.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / cyclohexane; diethyl ether / -78 - -50 °C / Inert atmosphere

3.2: -70 °C / Inert atmosphere

3.3: 0 °C / Inert atmosphere

4.1: sodium tetrahydroborate; methanol / 0.5 h / 0 - 23 °C

5.1: 1H-imidazole / N,N-dimethyl-formamide / 3 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 1.5 h / 23 °C

7.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 1 h / 20 °C

7.2: 20 °C

With 1H-imidazole; methanol; sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; di-tert-butyl dicarbonate; sec.-butyllithium; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; cyclohexane; water; N,N-dimethyl-formamide;

Reference yield:

: 109152-46-7
(+)-(S)-3-methylpiperidine-(+)-mandelate

: 1268817-70-4
2-(2-{[(2S,5S)-2-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-5-methyl-1-piperidinyl]carbonyl}-6-methyl-3-pyridinyl)pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; di-tert-butyl dicarbonate / water; tetrahydrofuran / 1 h / 0 - 20 °C

2.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / cyclohexane; diethyl ether / -78 - -50 °C / Inert atmosphere

2.2: -70 °C / Inert atmosphere

2.3: 0 °C / Inert atmosphere

3.1: sodium tetrahydroborate; methanol / 0.5 h / 0 - 23 °C

4.1: 1H-imidazole / N,N-dimethyl-formamide / 3 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1.5 h / 23 °C

6.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 1 h / 20 °C

6.2: 20 °C

With 1H-imidazole; methanol; sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; di-tert-butyl dicarbonate; sec.-butyllithium; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane; water; N,N-dimethyl-formamide;