17-Acetoxy-5a-androsta-2,16-diene

Base Information

Chemical Name:17-Acetoxy-5a-androsta-2,16-diene
CAS No.:50588-42-6
Molecular Formula:C₂₁H₃₀O₂
Molecular Weight:314.468
Hs Code.:
Mol file:50588-42-6.mol

Synonyms:Androsta-2,16-dien-17-ol,acetate, (5a)- (9CI);

Suppliers and Price of 17-Acetoxy-5a-androsta-2,16-diene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
(5α)-Androsta-2,16-dien-17-ol17-Acetate
250 mg
$ 650.00

Matrix Scientific
17-Acetoxy-5alpha-androsta-2,16-diene 95+%
250mg
$ 416.00

AK Scientific
17-Acetoxy-5a-androsta-2,16-diene
1g
$ 195.00

AccelPharmtech
17-Acetoxy-5a-androsta-2,16-diene 98%
5G
$ 140.00

Total 79 raw suppliers

Chemical Property of 17-Acetoxy-5a-androsta-2,16-diene

Chemical Property:

Vapor Pressure:0.001Pa at 25℃
Refractive Index:1.547
Boiling Point:413.2 °C at 760 mmHg
Flash Point:174.4 °C
PSA：26.30000
Density:1.07 g/cm³
LogP:5.25210
Storage Temp.:2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(5α)-Androsta-2,16-dien-17-ol17-Acetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 17-Acetoxy-5a-androsta-2,16-diene is a reactant used in the preparation of Rocuronium (R639500) and its derivatives.

Technology Process of 17-Acetoxy-5a-androsta-2,16-diene

There total 4 articles about 17-Acetoxy-5a-androsta-2,16-diene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 108-22-5
Isopropenyl acetate

: 14639-79-3,24174-20-7,82467-84-3,963-75-7
5α-androst-2-en-17-one

: 50588-42-6
17-acetoxy-5α-androsta-2,16-diene

Guidance literature:: With sulfuric acid;

Reference yield:

: 481-29-8
Epiandrosterone

: 50588-42-6
17-acetoxy-5α-androsta-2,16-diene

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 20 h / 20 °C

2: acetic acid; acetic anhydride; sodium acetate / 2 h / Reflux

3: sulfuric acid / 6 h / 20 °C

With pyridine; sulfuric acid; sodium acetate; acetic anhydride; acetic acid;
DOI:10.1016/j.steroids.2021.108928

Reference yield:

: 10429-07-9
3β-tosyloxy-5α-androstan-17-one

: 50588-42-6
17-acetoxy-5α-androsta-2,16-diene

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; acetic anhydride; sodium acetate / 2 h / Reflux

2: sulfuric acid / 6 h / 20 °C

With sulfuric acid; sodium acetate; acetic anhydride; acetic acid;
DOI:10.1016/j.steroids.2021.108928