5-Acetyloxindole

Base Information

• Chemical Name: 5-Acetyloxindole
• CAS No.: 64483-69-8
• Molecular Formula: C10H9 N O2
• Molecular Weight: 175.18
• Hs Code.: 2933790090
• European Community (EC) Number: 846-866-0
• DSSTox Substance ID: DTXSID00436865
• Wikidata: Q72435518
• Mol file: 64483-69-8.mol

Synonyms:5-ACETYLOXINDOLE;64483-69-8;5-acetylindolin-2-one;5-acetyl-1,3-dihydroindol-2-one;5-acetyl-2,3-dihydro-1H-indol-2-one;2H-Indol-2-one, 5-acetyl-1,3-dihydro-;5-Acetyl-2-oxindole;5-acetyl-2-indolinone;SCHEMBL688076;DTXSID00436865;HRMQSJQDTTZJPC-UHFFFAOYSA-N;AMY22858;5-acetyl-1,3-dihydro-indol-2-one;5-ethanoyl-1,3-dihydroindol-2-one;MFCD07782089;AKOS000152209;SB64245;TS-02420;CS-0043733;FT-0640953;EN300-41953;H10574;AB01000125-01;A834767;Z285150676

Chemical Property of 5-Acetyloxindole

Chemical Property:

• Melting Point: 225-227 °C
• Boiling Point: 418.4±45.0 °C(Predicted)
• PKA: 13.46±0.20(Predicted)
• PSA: 46.17000
• Density: 1.228±0.06 g/cm3(Predicted)
• LogP: 1.52180
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 175.063328530
• Heavy Atom Count: 13
• Complexity: 249

Purity/Quality:

97% ^*data from raw suppliers

5-Acetyloxindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC2=C(C=C1)NC(=O)C2

Technology Process of 5-Acetyloxindole

There total 3 articles about 5-Acetyloxindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.3%

2-oxoindole (59-48-3) + acetyl chloride (75-36-5) → 5-acetylindolin-2-one (64483-69-8)

Guidance literature:

acetyl chloride; With aluminum (III) chloride; In 1,2-dichloro-ethane; at 0 - 10 ℃; for 1h;

2-oxoindole; In 1,2-dichloro-ethane; at 0 - 20 ℃;

Reference yield: 86.3%

2-oxoindole (59-48-3) → 5-acetylindolin-2-one (64483-69-8)

Guidance literature:

acetyl chloride; With aluminum (III) chloride; In 1,2-dichloro-ethane; at 0 - 10 ℃; for 1h;

2-oxoindole; In 1,2-dichloro-ethane; at 10 - 20 ℃;

Reference yield: 73.0%

2-oxoindole (59-48-3) + acetyl chloride (75-36-5) → 5-acetylindolin-2-one (64483-69-8) + 5-acetyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one

Guidance literature:

In 1,2-dichloro-ethane;

upstream raw materials:

2-oxoindole

acetyl chloride

Downstream raw materials:

1-(N-benzoylcarbamoyl)-5-acetyloxindole

(Z)-1,1'-(3-(ethoxy(phenyl)methylene)-2-oxoindoline-1,5-diyl)bis(ethan-1-one)

5-ethyl-2-(2',3',5',6'-tetrafluoroanilino)-phenylacetic acid