Technology Process of ((E)-4-Phenyl-but-3-enyl)-phosphonic acid diethyl ester
There total 5 articles about ((E)-4-Phenyl-but-3-enyl)-phosphonic acid diethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Diethyl methylphosphonate;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.333333h;
3-bromo-1-phenyl-1-propenyl bromide;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.833333h;
DOI:10.1021/acs.orglett.1c03815
- Guidance literature:
-
With
C19H44ClP2Pd; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate;
In
toluene;
at 80 ℃;
for 16h;
diastereoselective reaction;
Sealed tube;
Inert atmosphere;
Glovebox;
Schlenk technique;
DOI:10.1021/jacs.9b09373
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.25 h / 23 °C / Inert atmosphere
1.2: Horner-Wadsworth-Emmons Olefination / 0.5 h / 0 - 23 °C / Inert atmosphere
2.1: sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; C19H44ClP2Pd / toluene / 16 h / 80 °C / Sealed tube; Inert atmosphere; Glovebox; Schlenk technique
With
C19H44ClP2Pd; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; lithium chloride;
In
toluene; acetonitrile;
1.1: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jacs.9b09373
