2-Amino-3-acetylpyridine

Base Information

• Chemical Name: 2-Amino-3-acetylpyridine
• CAS No.: 65326-33-2
• Molecular Formula: C7H8N2O
• Molecular Weight: 136.153
• Hs Code.: 2933399090
• European Community (EC) Number: 962-528-6
• DSSTox Substance ID: DTXSID50507655
• Wikidata: Q72437693
• Mol file: 65326-33-2.mol

Synonyms:65326-33-2;1-(2-aminopyridin-3-yl)ethanone;2-AMINO-3-ACETYLPYRIDINE;3-Acetyl-2-aminopyridine;1-(2-Amino-3-pyridinyl)-1-ethanone;1-(2-aminopyridin-3-yl)ethan-1-one;1-(2-Amino-pyridin-3-yl)-ethanone;MFCD02258895;ETHANONE, 1-(2-AMINO-3-PYRIDINYL)-;Azetyl-a-aminopyridin;SCHEMBL1322157;DTXSID50507655;BNVLGAQNNFJKHG-UHFFFAOYSA-N;AKOS005072803;FB-0601;AC-25564;SY040774;A1760;AM20061414;CS-0002197;FT-0650491;1-(2-Amino-3-pyridinyl)ethanone, AldrichCPR;F13139;J-502938

Chemical Property of 2-Amino-3-acetylpyridine

Chemical Property:

• Vapor Pressure: 0.00309mmHg at 25°C
• Melting Point: 139-140°C
• Refractive Index: 1.577
• Boiling Point: 283.8 °C at 760 mmHg
• PKA: 4.73±0.36(Predicted)
• Flash Point: 125.5 °C
• PSA: 55.98000
• Density: 1.168 g/cm³
• LogP: 1.44760
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 136.063662883
• Heavy Atom Count: 10
• Complexity: 136

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-3-acetylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=C(N=CC=C1)N

Technology Process of 2-Amino-3-acetylpyridine

There total 9 articles about 2-Amino-3-acetylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(2-pivaloylaminopyridin-3-yl)ethanone (161987-58-2) → 1-(2-amino-3-pyridinyl)-1-ethanone (65326-33-2)

Guidance literature:

With hydrogenchloride; for 14h; Heating;

DOI:10.1016/0040-4020(94)00922-H

Reference yield: 90.0%

1-(2-fluoropyridin-3-yl)ethan-1-one (79574-70-2) → 1-(2-amino-3-pyridinyl)-1-ethanone (65326-33-2)

Guidance literature:

With ammonia; In water; Heating;

DOI:10.1016/S0022-328X(00)80124-2

Reference yield: 90.0%

3-acetyl-2-chloropyridine (55676-21-6) → 1-(2-amino-3-pyridinyl)-1-ethanone (65326-33-2)

Guidance literature:

With ammonium hydroxide; at 100 ℃; for 2h;

upstream raw materials:

3-acetyl-2-chloropyridine

1-(2-fluoropyridin-3-yl)ethan-1-one

1-(2-pivaloylaminopyridin-3-yl)ethanone

2-(pivaloylamino)pyridine

Downstream raw materials:

1-benzyl-4-methyl-1,8-naphthyridin-(1H)2-one-3-carboxylic acid

ethyl 1-benzyl-4-methyl-1,8-naphthyridin-(1H)2-one-3-carboxylate

2-bromoethyl 1-benzyl-4-methyl-1,8-naphthyridin-(1H)2-one-3-carboxylate

tert-butyl (3-acetylpyridin-2-yl)carbamate