2-(2-Aminobenzoyl)pyridine

Base Information

• Chemical Name: 2-(2-Aminobenzoyl)pyridine
• CAS No.: 42471-56-7
• Molecular Formula: C12H10N2O
• Molecular Weight: 198.224
• Hs Code.: 2933399090
• European Community (EC) Number: 672-289-7
• DSSTox Substance ID: DTXSID70373410
• Nikkaji Number: J2.826.219A
• Wikidata: Q72438152
• Mol file: 42471-56-7.mol

Synonyms:2-(2-Aminobenzoyl)pyridine;42471-56-7;(2-Aminophenyl)(pyridin-2-yl)methanone;(2-aminophenyl)-pyridin-2-ylmethanone;2-Aminophenyl 2-pyridyl ketone;(2-aminophenyl)(2-pyridinyl)methanone;(2-Aminophenyl)pyridin-2-ylmethanone;SCHEMBL367924;2-(pyrid-2-ylcarbonyl)aniline;2-(pyridine-2-carbonyl)aniline;AMY1822;DTXSID70373410;3-Acetylthio-2-benzylpropanicacid;WEWXXYDHYCDEKY-UHFFFAOYSA-N;2-Aminophenyl(2-pyridinyl) ketone;MFCD03839744;(2-Aminophenyl)-2-pyridinylmethanone;(2-aminophenyl)-(2-pyridyl)methanone;AKOS006346230;MS-8510;SB53946;(2-Aminophenyl)(pyridine-2-yl)methanone;(2-amino-phenyl)-pyridin-2-yl-methanone;CS-0317845;FT-0690263;F87885;A825911;F0001-1179

Chemical Property of 2-(2-Aminobenzoyl)pyridine

Chemical Property:

• Vapor Pressure: 5.6E-07mmHg at 25°C
• Melting Point: 153-155 °C
• Refractive Index: 1.634
• Boiling Point: 411.398 °C at 760 mmHg
• PKA: 2.75±0.10(Predicted)
• Flash Point: 202.607 °C
• PSA: 55.98000
• Density: 1.216 g/cm³
• LogP: 2.47600
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly, Heated)
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 198.079312947
• Heavy Atom Count: 15
• Complexity: 230

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Aminobenzoyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)C2=CC=CC=N2)N
• Uses: 2-(2-Aminobenzoyl)pyridine, is an intermediate used for the synthesis of various Quinoline derivatives. It can also be used in the synthesis of the antitumoral agent batracylin and related isoindolo[1,2-b]quinazolin-12(10H)-ones.

Technology Process of 2-(2-Aminobenzoyl)pyridine

There total 10 articles about 2-(2-Aminobenzoyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

anthranilic acid nitrile (1885-29-6) → 2-(2-aminobenzoyl)pyridine (42471-56-7)

Guidance literature:

With hydrogenchloride; In hexane; toluene;

Reference yield: 84.0%

2-bromo-pyridine (109-04-6) + anthranilic acid nitrile (1885-29-6) → 2-(2-aminobenzoyl)pyridine (42471-56-7)

Guidance literature:

With n-butyllithium; In hexane; toluene; at -50 ℃; for 1h; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201403891

Reference yield: 63.0%

2-pyridyllithium (17624-36-1) + anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 2-(2-aminobenzoyl)pyridine (42471-56-7)

Guidance literature:

In tetrahydrofuran; diethyl ether; hexane; at 0 ℃; for 2h;

DOI:10.1080/00397919308013295

upstream raw materials:

(2-nitrophenyl)(pyridin-2-yl)methanone

benzoic acid-[2-(pyridine-2-carbonyl)-anilide]

2-pyridyllithium

anthranilic acid

Downstream raw materials:

1-(2-amino-phenyl)-1-[2]pyridyl-ethanol

3-nitro-4-[2]pyridyl-quinoline

4-pyridin-2-yl-1H-quinazolin-2-one

2--N^α-(benzyloxycarbonyl)glycinyl>-2'-aminobenzoyl>pyridine