D-Homoserine Lactone hydrochloride

Base Information

• Chemical Name: D-Homoserine Lactone hydrochloride
• CAS No.: 104347-13-9
• Molecular Formula: C4H7NO2^.HCl
• Molecular Weight: 137.566
• Hs Code.: 2932209090
• European Community (EC) Number: 625-402-9
• DSSTox Substance ID: DTXSID00474646
• Mol file: 104347-13-9.mol

Synonyms:104347-13-9;D-Homoserine Lactone hydrochloride;(R)-(+)-alpha-Amino-gamma-butyrolactone hydrochloride;(R)-3-aminodihydrofuran-2(3H)-one hydrochloride;D-HOMOSERINE LACTONE HCL;(3R)-3-aminooxolan-2-one;hydrochloride;MFCD00674071;D-(+)-Homoserine Lactone Hydrochloride;2(3H)-Furanone, 3-aminodihydro-, hydrochloride, (3R)-;(R)-(+)-3-Aminotetrahydrofuran-2-one Hydrochloride;(3R)-3-aminotetrahydrofuran-2-one hydrochloride;(3R)-3-aminooxolan-2-one Hydrochloride;D-HomoserineLactonehydrochloride;SCHEMBL1402931;DTXSID00474646;XBKCXPRYTLOQKS-AENDTGMFSA-N;AMY22572;(R)-3-Aminodihydrofuran-2-one HCl;FD1142;AKOS015849335;CS-W011054;AC-23765;DS-13294;(R)-a-amino-gamma-butyrolactone hydrochloride;(R)-(+)-a-Amino-g-butyrolactone hydrochloride;(R)-3-amino-dihydro-furan-2-one hydrochloride;(R)-(+)- -Amino-?-butyrolactone hydrochloride;EN300-7395766;(3R)-3-aminodihydrofuran-2(3H)-one hydrochloride;A800962;(R)-(+)-alpha-Amino- -butyrolactone hydrochloride;J-001153;(R)-(+)- alpha -Amino- -butyrolactone hydrochloride;(R)-(+)-alpha-Amino-gamma-butyrolactone hydrochloride, 97%;D-Homoserine lactone hydrochloride, (R)-2-Amino-4-butyrolactone hydrochloride (H-D-Hsl.HCl)

Chemical Property of D-Homoserine Lactone hydrochloride

Chemical Property:

• Vapor Pressure: 0.0148mmHg at 25°C
• Melting Point: 220-224 °C
• Boiling Point: 257.1 °C at 760 mmHg
• Flash Point: 120.1 °C
• PSA: 52.32000
• LogP: 0.76290
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: Soluble in water
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 137.0243562
• Heavy Atom Count: 8
• Complexity: 91.7

Purity/Quality:

99% ^*data from raw suppliers

D-Homoserine Lactone Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(=O)C1N.Cl
• Isomeric SMILES: C1COC(=O)[C@@H]1N.Cl

Technology Process of D-Homoserine Lactone hydrochloride

There total 7 articles about D-Homoserine Lactone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(R)-3-((R)-2-Hydroxy-1-phenyl-ethylamino)-dihydro-furan-2-one; hydrochloride → (R)-(+)-α-amino-γ-butyrolactone hydrochloride (104347-13-9)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; for 72h; under 760 Torr;

DOI:10.1016/S0040-4020(01)87201-X

Reference yield: 61.0%

C7H16NO2S(1+) → (R)-(+)-α-amino-γ-butyrolactone hydrochloride (104347-13-9)

Guidance literature:

With hydrogenchloride; In water; for 4h; Reflux;

Reference yield: 47.0%

α-Phenylacetamido-γ-Butyrolactone (500720-04-7,55154-48-8) → phenylacetic acid (103-82-2) + (R)-(+)-α-amino-γ-butyrolactone hydrochloride (104347-13-9) + (S)-N-(2-oxo-tetrahydrofuran-3-yl)-2-phenylacetamide (55154-48-8)

Guidance literature:

α-Phenylacetamido-γ-Butyrolactone; With ammonia; water; at 25 ℃; for 1h; pH=7.5; Enzymatic reaction;

With hydrogenchloride; In water; pH=2; enantioselective reaction;

DOI:10.1016/j.tetasy.2011.10.015

upstream raw materials:

2-Amino-4-(2-methoxy-ethoxymethoxy)-butyric acid methyl ester

(RS)-α-amino-γ-butyrolactone hydrochloride

D-methionine

α-Phenylacetamido-γ-Butyrolactone

Downstream raw materials:

D-homoserine

(R)-2-[(tert-butoxycarbonyl)amino]butano-4-lactone

3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)-N-[(3R)-2-oxotetrahydro-3-furanyl]benzamide

(R)-(+)-N-heptanoylhomoserine lactone