5-[2-(1-tert-butoxycarbonyl-piperidin-2-yl)-vinyl]-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Base Information

• Chemical Name: 5-[2-(1-tert-butoxycarbonyl-piperidin-2-yl)-vinyl]-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester
• CAS No.: 220384-50-9
• Molecular Formula: C₂₅H₃₄N₂O₄
• Molecular Weight: 426.556

Synonyms:5-[2-(1-tert-butoxycarbonyl-piperidin-2-yl)-vinyl]-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Chemical Property of 5-[2-(1-tert-butoxycarbonyl-piperidin-2-yl)-vinyl]-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Chemical Property:

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Technology Process of 5-[2-(1-tert-butoxycarbonyl-piperidin-2-yl)-vinyl]-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

There total 1 articles about 5-[2-(1-tert-butoxycarbonyl-piperidin-2-yl)-vinyl]-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

rac-2-vinylpiperidine-1-carboxylic acid tert-butyl ester (132910-76-0,176324-61-1) + Benzyl 1,2,3,4-tetrahydro-5-<(trifluoromethyl)sulfonyloxy>-pyridine-1-carboxylate (149108-73-6) → 5-[2-(1-tert-butoxycarbonyl-piperidin-2-yl)-vinyl]-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester (220384-50-9)

Guidance literature:

With palladium diacetate; tetrabutylammonium trifluoromethylsulfonate; potassium carbonate; In N,N-dimethyl-formamide; at 55 ℃;

DOI:10.1021/ja983013+

Reference yield:

5-[2-(1-tert-butoxycarbonyl-piperidin-2-yl)-vinyl]-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester (220384-50-9) → (4aR,4bS,9aS,10S,10aR)-11-Oxo-2,3,4,4a,4b,6,7,8,9a,10,10a,11-dodecahydro-1H-9,11a-diaza-benzo[b]fluorene-9,10-dicarboxylic acid 9-benzyl ester 10-ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: TFA

2: pyridine / CH₂Cl₂ / 0 °C

With pyridine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ja983013+

Reference yield:

5-[2-(1-tert-butoxycarbonyl-piperidin-2-yl)-vinyl]-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester (220384-50-9) → 5-(2-piperidin-2-yl-vinyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Guidance literature:

With trifluoroacetic acid;

DOI:10.1021/ja983013+

upstream raw materials:

rac-2-vinylpiperidine-1-carboxylic acid tert-butyl ester

Benzyl 1,2,3,4-tetrahydro-5-<(trifluoromethyl)sulfonyloxy>-pyridine-1-carboxylate

Downstream raw materials:

5-[2-(1-methanesulfonyl-piperidin-2-yl)-vinyl]-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

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