N-[2-(2-bromo-5-hydroxy-4-methoxyphenyl)ethyl]-N-[(S)-1-phenylethyl]-2-(2-bromo-4,5-dimethoxyphenyl)acetamide

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Chemical Name:N-[2-(2-bromo-5-hydroxy-4-methoxyphenyl)ethyl]-N-[(S)-1-phenylethyl]-2-(2-bromo-4,5-dimethoxyphenyl)acetamide
CAS No.:342901-86-4
Molecular Formula:C₂₇H₂₉Br₂NO₅
Molecular Weight:607.339
Hs Code.:

Synonyms:N-[2-(2-bromo-5-hydroxy-4-methoxyphenyl)ethyl]-N-[(S)-1-phenylethyl]-2-(2-bromo-4,5-dimethoxyphenyl)acetamide

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Chemical Property of N-[2-(2-bromo-5-hydroxy-4-methoxyphenyl)ethyl]-N-[(S)-1-phenylethyl]-2-(2-bromo-4,5-dimethoxyphenyl)acetamide

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Technology Process of N-[2-(2-bromo-5-hydroxy-4-methoxyphenyl)ethyl]-N-[(S)-1-phenylethyl]-2-(2-bromo-4,5-dimethoxyphenyl)acetamide

There total 5 articles about N-[2-(2-bromo-5-hydroxy-4-methoxyphenyl)ethyl]-N-[(S)-1-phenylethyl]-2-(2-bromo-4,5-dimethoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.35%

: 342901-84-2
N-[2-(5-benzyloxy-2-bromo-4-methoxyphenyl)ethyl]-N-[(S)-1-phenylethyl]-2-(2-bromo-4,5-dimethoxyphenyl)acetamide

: 342901-86-4
N-[2-(2-bromo-5-hydroxy-4-methoxyphenyl)ethyl]-N-[(S)-1-phenylethyl]-2-(2-bromo-4,5-dimethoxyphenyl)acetamide

Guidance literature:: With tin(IV) chloride; In benzene; at 20 ℃; for 4h;
DOI:10.3987/com-00-9151

Reference yield:

: 13425-04-2
5-benzyloxy-4-methoxy-2-bromophenylacetic acid

: 342901-86-4
N-[2-(2-bromo-5-hydroxy-4-methoxyphenyl)ethyl]-N-[(S)-1-phenylethyl]-2-(2-bromo-4,5-dimethoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂

2: 96.7 percent / Na₂CO₃ / diethyl ether / 2 h / 10 - 15 °C

3: 92.4 percent / BF₃*Et₂O; BH₃*THF / tetrahydrofuran / 2.5 h / 70 °C

4: 79.7 percent / Na₂CO₃ / diethyl ether / 2 h / 10 - 15 °C

5: 11.35 percent / SnCl₄ / benzene / 4 h / 20 °C

With thionyl chloride; borane-THF; boron trifluoride diethyl etherate; tin(IV) chloride; sodium carbonate; In tetrahydrofuran; diethyl ether; benzene;
DOI:10.3987/com-00-9151

Reference yield:

: 86639-19-2
5-benzyloxy-2-bromo-4-methoxyphenylacetic acid chloride

: 342901-86-4
N-[2-(2-bromo-5-hydroxy-4-methoxyphenyl)ethyl]-N-[(S)-1-phenylethyl]-2-(2-bromo-4,5-dimethoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 96.7 percent / Na₂CO₃ / diethyl ether / 2 h / 10 - 15 °C

2: 92.4 percent / BF₃*Et₂O; BH₃*THF / tetrahydrofuran / 2.5 h / 70 °C

3: 79.7 percent / Na₂CO₃ / diethyl ether / 2 h / 10 - 15 °C

4: 11.35 percent / SnCl₄ / benzene / 4 h / 20 °C

With borane-THF; boron trifluoride diethyl etherate; tin(IV) chloride; sodium carbonate; In tetrahydrofuran; diethyl ether; benzene;
DOI:10.3987/com-00-9151