(1R,2S)-cis-2-Aminocyclopentanol hydrochloride

Base Information

• Chemical Name: (1R,2S)-cis-2-Aminocyclopentanol hydrochloride
• CAS No.: 137254-03-6
• Molecular Formula: C₅H₁₁NO*ClH
• Molecular Weight: 137.609
• Hs Code.: 2922190090
• Mol file: 137254-03-6.mol

Synonyms:Cyclopentanol,2-amino-, hydrochloride, (1R,2S)- (9CI);Cyclopentanol, 2-amino-,hydrochloride, (1R-cis)-;(1R,2S)-2-Aminocyclopentanol hydrochloride;cis-(1R)-2-Aminocyclopentanolhydrochloride;(1R-cis)-2-Aminocyclopentanol hydrochloride;

Chemical Property of (1R,2S)-cis-2-Aminocyclopentanol hydrochloride

Chemical Property:

• PSA: 46.25000
• LogP: 1.36080
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

(1R,2S)-2-Aminocyclopentanolhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 38-41
• Safety Statements: 29-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R,2S)-cis-2-Aminocyclopentanol hydrochloride

There total 4 articles about (1R,2S)-cis-2-Aminocyclopentanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-2-(4-nitro-phenyl)-(3ar,6ac)-4,5,6,6a-tetrahydro-3aH-cyclopentoxazole (16936-83-7,18721-47-6,33092-75-0) → cis-aminotetrahydro-3-furanol hydrochloride (31775-67-4,31889-37-9,33092-89-6,68327-04-8,68327-11-7,98137-42-9,137254-03-6)

Guidance literature:

With hydrogenchloride; water;

DOI:10.1021/ja01161a089

Reference yield:

trans-2-aminocyclopentanol (33092-86-3) → cis-aminotetrahydro-3-furanol hydrochloride (31775-67-4,31889-37-9,33092-89-6,68327-04-8,68327-11-7,98137-42-9,137254-03-6)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂O; benzene; aq. NaOH solution

2: SOCl₂

3: water; HCl

With hydrogenchloride; sodium hydroxide; thionyl chloride; water; benzene;

DOI:10.1021/ja01161a089

Reference yield:

(+/-)-4-nitro-benzoic acid-(trans-2-hydroxy-cyclopentylamide) (33092-88-5,100135-54-4) → cis-aminotetrahydro-3-furanol hydrochloride (31775-67-4,31889-37-9,33092-89-6,68327-04-8,68327-11-7,98137-42-9,137254-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂

2: water; HCl

With hydrogenchloride; thionyl chloride; water;

DOI:10.1021/ja01161a089

upstream raw materials:

(+/-)-2-(4-nitro-phenyl)-(3ar,6ac)-4,5,6,6a-tetrahydro-3aH-cyclopentoxazole

trans-2-aminocyclopentanol

(+/-)-4-nitro-benzoic acid-(trans-2-hydroxy-cyclopentylamide)